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Purposeful alteration of [99mTc]-pertechnetate biodistribution
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1989A series of imaging studies were conducted in rats to assess the effect of stannous containing chemical species on the normal biodistribution of [99mTc]pertechnetate. The goal of the study was to determine if tissue activity could be altered by use of selected chemical agents and if such alteration could be used to clear non-target activity for ...
W A, Pettit, R M, Beihn
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In VivoBiodistribution of Nanoparticles
Nanomedicine, 2011Nanoparticles have potential applications in diagnostics, imaging, gene and drug delivery and other types of therapy. Iron oxide nanoparticles, gold nanoparticles and quantum dots have all generated substantial interest and their properties and applications have been thoroughly studied. Yet, metal-containing particles raise biodistribution and toxicity
Joao Paulo Mattos, Almeida +3 more
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Bioavailability and biodistribution of nanodelivered lutein
Food Chemistry, 2016The aim of the study was to evaluate the ability of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) to enhance lutein bioavailability. The bioavailability of free lutein and PLGA-NP lutein in rats was assessed by determining plasma pharmacokinetics and deposition in selected tissues. Lutein uptake and secretion was also assessed in Caco-2 cells.
Alison, Kamil +5 more
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The Biodistribution of Radiocopper-Labeled Compounds
1989Porphyrins form extremely stable chelates with Cu2+. Two copper radionuclides, 67Cu and 64Cu, have attractive nuclear decay properties for use in nuclear medicine applications. We have investigated the use of radiocopper-labeled porphyrins for localization in inflamed tissue and for attachment to antibodies for tumor imaging and therapy.
J A, Mercer-Smith +5 more
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Biodistribution and Shedding of AAV Vectors
2011Determining the AAV vector biodistribution and shedding is central for the safety assessment of proposed early-phase clinical trials. It is especially crucial in the case of AAV vectors since they are injected directly in situ with no possibility of an intermediate ex vivo step, such as in retroviral-mediated approaches.
Caroline, Le Guiner +2 more
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The Biodistribution (III): Analysis
2010In this chapter, practical means of estimating the normalized cumulated activity from a measured discrete biodistribution set are reviewed. This involves the integration of these activity values from the time of administration to infinity. Least-squares fitting of the activity data by analytical functions, including the multiexponential form and the ...
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The Biodistribution (II): Human
2010The measurement of the distribution and excretion of the radionuclide following the administration of a radiopharmaceutical is necessary in order to evaluate the consequential internal radiation dosimetry. This chapter reviews various in vivo and in vitro means of acquiring these data.
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The Biodistribution (I): Preclinical
2010The measurement of the biodistribution of a radiopharmaceutical must be performed in the preclinical setting in order to provide an initial estimate of the internal radiation dosimetry of the human prior to the first-into-man Phase I study. This chapter summarizes both the means of how the preclinical biodistribution data are derived and how these data
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