Results 221 to 230 of about 63,325 (247)

Bioconjugation and biodistribution

2002
The term “bioconjugation ” usually defines the specific covalent linking between two biomolecules, in order to obtain a novel molecular entity with peculiar physicochemi-cal and biological properties (1). In medicine, bioconjugation is mainly exploited to impart biological specificity to drugs or diagnostics.
VERONESE F.M., CALICETI, PAOLO
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Liposome Biodistribution via Europium Complexes

2009
Vector biodistribution is a requirement prior pharmaceutical development. Radioactive tracers allow the most sensitive and quantitative assessment of biodistribution, and conventional fluorophores are widely used in academic laboratories. We propose here to use europium complexes as a label for nanoparticles or biotherapeutics taking liposomes as ...
Nathalie, Mignet, Daniel, Scherman
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Iatrogenic alterations in radionuclide biodistributions

Seminars in Nuclear Medicine, 1979
The biodistribution of radiotracers used in diagnostic imaging is grossly and recognizably altered by a wide variety of drugs and other treatment modalities, such as surgery and radiotherapy. Knowledge of such altered biodistribution is important both in making diagnostic inferences from scans and in dosimetric considerations.
B C, Lentle, J R, Scott, A A, Noujaim, F I, Jackson   +3 more
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Antithrombin III: Biodistribution in Healthy Volunteers

Thrombosis and Haemostasis, 1987
SummaryFive healthy volunteers were injected intravenously with 73-90 uCi purified human 131I-Antithrombin III (AT III), specific biological activity 5.6 U/mg. The tracer data were analysed using a three compartment model. The plasma radioactivity half life was 66.2 ± 1.2 (sem) h, the fractional catabolic rate constant of the plasma pool was 0.025 ± 0 ...
Knot, E. A., de Jong, E., ten Cate, J. W., Gie, L. K., van Royen, E. A.   +4 more
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Scintigraphic visualization of intrathecal liposome biodistribution

Acta Anaesthesiologica Scandinavica, 1997
Background: Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers. Therefore, we observed the biodistribution of liposomes after intrathecal injection in rats by scintigraphic imaging during 24 h.Methods: We administered
Umbrain, V, D'Haese, J, Alafandy, M, De Roover, E, Schoutens, A, Van Gansbeke, B, Albert, Adelin, Goffinet, Gerhard, Camu, F, Legros, F J   +9 more
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Biodegradation, biodistribution and toxicity of chitosan

Advanced Drug Delivery Reviews, 2010
Chitosan is a natural polysaccharide that has attracted significant scientific interest during the last two decades. It is a potentially biologically compatible material that is chemically versatile (-NH2 groups and various M(w)). These two basic properties have been used by drug delivery and tissue engineering scientists to create a plethora of ...
Kean, T., Thanou, M.
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Biodistribution of Radiolabeled Ethanol in Rodents

Drug Metabolism and Disposition, 2008
The biodistribution of [1-(14)C]ethanol in rodents was examined to determine sites of concentration of ethanol or its metabolites that may contribute to its toxicological and pharmacokinetic characteristics. After i.v. administration of [1-(14)C]ethanol in mice, radioactivity showed a widespread distribution among body organs.
Andrew N, Gifford, Mel Pilar, Espaillat, S John, Gatley   +2 more
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Biodistribution of radiolabeled lymphocytes.

Radiology, 1985
Factors that might affect the biodistribution and clinical utility of radiolabeled lymphocytes were evaluated in experimental animals. Indium-111 (In-111) labeled lymphocytes (10(7)-10(9) syngeneic or allogeneic cells; 1-10 microCi [.037-.37 MBq]/10(8) cells) obtained from peripheral blood, lymph node, or spleen were found in significant amounts in the
R A, Fawwaz, S, Oluwole, T S, Wang, N, Kuromoto, C, Iga, M A, Hardy, P O, Alderson   +6 more
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Biodistribution of covalent antithrombin-heparin complexes

Thrombosis and Haemostasis, 2006
SummaryWe have developed a covalent antithrombin-heparin (ATH) complex with advantages compared to non-covalent antithrombin: heparin (AT:H) mixtures. In addition to increased activity, ATH has a longer intravenous half-life that is partly due to reduced plasma protein binding.
Paul A, Chindemi, Petr, Klement, Filip, Konecny, Leslie R, Berry, Anthony K C, Chan   +4 more
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Purposeful alteration of [99mTc]-pertechnetate biodistribution

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1989
A series of imaging studies were conducted in rats to assess the effect of stannous containing chemical species on the normal biodistribution of [99mTc]pertechnetate. The goal of the study was to determine if tissue activity could be altered by use of selected chemical agents and if such alteration could be used to clear non-target activity for ...
W A, Pettit, R M, Beihn
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