Results 51 to 60 of about 67,723 (299)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Integrated regulation of antioxidant defence, photosystem II stability, and carbon metabolism drives drought tolerance in contrasting Sorghum bicolor genotypes

Discover Plants
Drought stress severely limits crop productivity by disrupting plant water status, redox balance and photosynthetic efficiency. This study aimed to identify key adaptive traits by comparing a drought-tolerant genotype (CSV 15) with a drought-sensitive ...
Manisha Rathore, Hanwant Singh, Deepak Kumar, Upma Bhatt, Yashwant Sompura, Vineet Soni   +5 more
doaj   +1 more source

Running Energy Reserve Index (RERI) as a new model for assessment and prediction of world, elite, sub-elite, and collegiate running performances

Scientific Reports, 2023
The purpose of this study was to utilize the Running Energy Reserve Index (RERI) model and two-trial procedure to predict all-out athletic performances. Twenty-nine trained athletes tested for differences between RERIE and RERIspd (hypothesis 1).
Govindasamy Balasekaran, Mun Keong Loh, Peggy Boey, Yew Cheo Ng   +3 more
doaj   +1 more source

Toxic effects of Rhodamine B on antioxidant system and photosynthesis of Hydrilla verticillata

Journal of Hazardous Materials Letters, 2022
Rhodamine B is a synthetic dye released in huge quantities as hazardous colored effluents into aquatic ecosystems. It negatively affects the metabolic and physiological processes in aquatic plants.
Jyotshana Sharma, Shubhangani Sharma, Upma Bhatt, Vineet Soni   +3 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

A-GAME: improving the assembly of pooled functional metagenomics sequence data

BMC Genomics, 2018
Background Expression screening of environmental DNA (eDNA) libraries is a popular approach for the identification and characterization of novel microbial enzymes with promising biotechnological properties.
Matteo Chiara, Antonio Placido, Ernesto Picardi, Luigi Ruggiero Ceci, David Stephen Horner, Graziano Pesole   +5 more
doaj   +1 more source

Role of Mitochondrial Glycerol-3-Phosphate Dehydrogenase in Metabolic Adaptations of Prostate Cancer

Cells, 2020
Prostate cancer is one of the most prominent cancers diagnosed in males. Contrasting with other cancer types, glucose utilization is not increased in prostate carcinoma cells as they employ different metabolic adaptations involving mitochondria as a ...
Alena Pecinová, Lukáš Alán, Andrea Brázdová, Marek Vrbacký, Petr Pecina, Zdeněk Drahota, Josef Houštěk, Tomáš Mráček   +7 more
doaj   +1 more source

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration [PDF]

, 2013
Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes.
Iain Hargreaves, Land, John M., Kira M. Holmström, Andrey Y. Abramov, Chalasani, A, Annapurna Chalasani, Holmstrom, KM, Masayuki Yamamoto, Baird, Liam, Baird, L, John M. Land, Yamamoto, Masayuki, Lee Stanyer, Land, JM, Dinkova-Kostova, AT, Holmström, Kira M., Liam Baird, Albena T. Dinkova-Kostova, Ying Zhang, Abramov, Andrey Y., Zhang, Y, Hargreaves, Iain, Chalasani, Annapurna, Abramov, AY, Stanyer, L, Hargreaves, IP, Yamamoto, M, Zhang, Ying, Stanyer, Lee, Dinkova-Kostova, Albena T.; id_orcid   +29 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Protein intake in cancer: Does it improve nutritional status and/or modify tumour response to chemotherapy?

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Combating malnutrition and cachexia is a core challenge in oncology. To limit muscle mass loss, the use of proteins in cancer is encouraged by experts in the field, but it is still debated due to their antagonist effects.
Martin Boutière, Cécile Cottet‐Rousselle, Céline Coppard, Karine Couturier, Catherine Féart, Morgane Couchet, Christelle Corne, Christophe Moinard, Charlotte Breuillard   +8 more
doaj   +1 more source