Results 51 to 60 of about 376,139 (290)
Bioengineering of the heart [PDF]
APL Bioengineering, 2020 Alberto Redaelli, Justin Cooper-White
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Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion [PDF]
, 2018 Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ...
Bouzos, Evangelia +6 more
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Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Site investigation for the effects of vegetation on ground stability [PDF]
, 2006 The procedure for geotechnical site investigation is well established but little attention is currently given to investigating the potential of vegetation to assist with ground stability.
A. Stokes +23 more
core +1 more source
TMJ Bioengineering: A review [PDF]
Journal of Oral Biology and Craniofacial Research, 2013 Regeneration using scaffolds, growth factors, and stem cells is being investigated worldwide. Pubmed search for scaffolds for condyle resulted in 102 articles, of which 24 analyzed Temporomandibular joint (TMJ) scaffolds and only 6 evaluated hydroxyapatite scaffolds. 17 articles report studies on TMJ disc regeneration.
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Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Numerical model for material parameter identification of cells [PDF]
, 2017 Bacteria have a complex external layer that render them with an increased stiffness and more resistant to external invasion. The works aims to model the squeezing of a bacteria between two walls, and deduce the composition of bacterial external layer ...
Roldán Blasco, Juan Pedro
core
The field of therapeutic medicine and drug discovery is undergoing a renaissance, marked by a renewed interest in natural products as a source of novel pharmaceuticals. In the age of advanced synthetic chemistry and biotechnology, the vast potential of natural compounds often remains untapped, yet history has repeatedly shown that nature harbors a ...
Srivastava, Arpit, Pandey, Ashutosh
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source