Results 61 to 70 of about 167,921 (294)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Assessment of the aerobic granulation process through quantitative image analysis [PDF]
, 2010 Este resumo faz parte de: Book of abstracts of the Meeting of the Institute for Biotechnology and Bioengineering, 2, Braga, Portugal, 2010.
Alves, M. M. +2 more
core
Characterizing steady states of genome-scale metabolic networks in continuous cell cultures
, 2017 We present a model for continuous cell culture coupling intra-cellular metabolism to extracellular variables describing the state of the bioreactor, taking into account the growth capacity of the cell and the impact of toxic byproduct accumulation.
Fernandez-de-Cossio-Diaz, Jorge +2 more
core +3 more sources
An ultra scale-down analysis of the recovery by dead-end centrifugation of human cells for therapy. [PDF]
, 2014 An ultra scale-down method is described to determine the response of cells to recovery by dead-end (batch) centrifugation under commercially defined manufacturing conditions.
Delahaye, M +3 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Intensified bioprocess for the anaerobic conversion of syngas to biofuels [PDF]
, 2010 Este resumo faz parte de: Book of abstracts of the Meeting of the Institute for Biotechnology and Bioengineering, 2, Braga, Portugal, 2010.
Alves, M. M. +3 more
core
Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology
BiomimeticsThe gut microbiota is a complex and dynamic ecosystem that plays a fundamental role in human health by regulating immunity, metabolism, and the gut–brain axis.
Ana Isabel Beltrán-Velasco +1 more
semanticscholar +1 more source
Biotechnology and Bioengineering: Volume 117, Number 1, January 2020
Biotechnology and Bioengineering, 2019 Funding information Engineering and Physical Sciences Research Council, Grant/Award Number: EP/ L01520X/1 Abstract Constraint‐based modeling methods, such as Flux Balance Analysis (FBA), have been extensively used to decipher complex, information rich ...
Robin Legner +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
STAR ProtocolsSummary: Here, we present a protocol for the development of mRNA-loaded lipid nanoparticle (LNP) vaccines for target antigen sequences of interest. We describe key steps required to design and synthesize mRNA constructs, their LNP encapsulation, and ...
Neha Karekar +8 more
doaj +1 more source