Results 161 to 170 of about 431,520 (211)
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BioEssays, 1997
AbstractPeroxisomes are eukaryotic organelles that are the subcellular location of important metabolic reactions. In humans, defects in the organelle's function are often lethal. Yet, relative to other organelles, little is known about how cells maintain and propagate peroxisomes or how they direct specific sets of newly synthesized proteins to these ...
H R, Waterham, J M, Cregg
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AbstractPeroxisomes are eukaryotic organelles that are the subcellular location of important metabolic reactions. In humans, defects in the organelle's function are often lethal. Yet, relative to other organelles, little is known about how cells maintain and propagate peroxisomes or how they direct specific sets of newly synthesized proteins to these ...
H R, Waterham, J M, Cregg
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Annual Review of Cell and Developmental Biology, 2001
▪ Abstract Fifteen years ago, we had a model of peroxisome biogenesis that involved growth and division of preexisting peroxisomes. Today, thanks to genetically tractable model organisms and Chinese hamster ovary cells, 23 PEX genes have been cloned that encode the machinery (“peroxins”) required to assemble the organelle.
P E, Purdue, P B, Lazarow
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▪ Abstract Fifteen years ago, we had a model of peroxisome biogenesis that involved growth and division of preexisting peroxisomes. Today, thanks to genetically tractable model organisms and Chinese hamster ovary cells, 23 PEX genes have been cloned that encode the machinery (“peroxins”) required to assemble the organelle.
P E, Purdue, P B, Lazarow
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Journal of Theoretical Biology, 1997
In the biological sense, biogenesis is the spontaneous assembly of program-controlled, self-reproducing fluid automata under prebiotic conditions. In order to understand this phenomenon, principles of the theory of fluid automata should be laid down, as well as those of cycle stoichiometry which makes the exact, quantitative design of such chemically ...
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In the biological sense, biogenesis is the spontaneous assembly of program-controlled, self-reproducing fluid automata under prebiotic conditions. In order to understand this phenomenon, principles of the theory of fluid automata should be laid down, as well as those of cycle stoichiometry which makes the exact, quantitative design of such chemically ...
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2003
Peroxisome biogenesis conceptually consists of the (a) formation of the peroxisomal membrane, (b) import of proteins into the peroxisomal matrix and (c) proliferation of the organelles. Combined genetic and biochemical approaches led to the identification of 25 PEX genes-encoding proteins required for the biogenesis of peroxisomes, so-called peroxins ...
J H, Eckert, R, Erdmann
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Peroxisome biogenesis conceptually consists of the (a) formation of the peroxisomal membrane, (b) import of proteins into the peroxisomal matrix and (c) proliferation of the organelles. Combined genetic and biochemical approaches led to the identification of 25 PEX genes-encoding proteins required for the biogenesis of peroxisomes, so-called peroxins ...
J H, Eckert, R, Erdmann
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2012
Mature crRNAs are key elements in CRISPR-Cas defense against genome invaders. These short RNAs are composed of unique repeat/spacer sequences that guide the Cas protein(s) to the cognate invading nucleic acids for their destruction. The biogenesis of mature crRNAs involves highly precise processing events.
Charpentier, E. +2 more
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Mature crRNAs are key elements in CRISPR-Cas defense against genome invaders. These short RNAs are composed of unique repeat/spacer sequences that guide the Cas protein(s) to the cognate invading nucleic acids for their destruction. The biogenesis of mature crRNAs involves highly precise processing events.
Charpentier, E. +2 more
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Biochemistry (Moscow), 2016
The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by ...
O P, Kisurina-Evgenieva +2 more
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The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by ...
O P, Kisurina-Evgenieva +2 more
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Annual Review of Cell and Developmental Biology, 1999
▪ Abstract Synaptic vesicles, which have been a paradigm for the fusion of a vesicle with its target membrane, also serve as a model for understanding the formation of a vesicle from its donor membrane. Synaptic vesicles, which are formed and recycled at the periphery of the neuron, contain a highly restricted set of neuronal proteins.
M J, Hannah, A A, Schmidt, W B, Huttner
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▪ Abstract Synaptic vesicles, which have been a paradigm for the fusion of a vesicle with its target membrane, also serve as a model for understanding the formation of a vesicle from its donor membrane. Synaptic vesicles, which are formed and recycled at the periphery of the neuron, contain a highly restricted set of neuronal proteins.
M J, Hannah, A A, Schmidt, W B, Huttner
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Biochimie, 2001
26S proteasomes are multi-subunit protease complexes responsible for the turnover of short-lived proteins. Proteasomal degradation starts with the autocatalytic maturation of the 20S core particle. Here, we summarize different models of proteasome assembly.
E, Krüger, P M, Kloetzel, C, Enenkel
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26S proteasomes are multi-subunit protease complexes responsible for the turnover of short-lived proteins. Proteasomal degradation starts with the autocatalytic maturation of the 20S core particle. Here, we summarize different models of proteasome assembly.
E, Krüger, P M, Kloetzel, C, Enenkel
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Peroxisome Biogenesis Disorders
2020Peroxisomes are presented in all eukaryotic cells and play essential roles in many of lipid metabolic pathways, including β-oxidation of fatty acids and synthesis of ether-linked glycerophospholipids, such as plasmalogens. Impaired peroxisome biogenesis, including defects of membrane assembly, import of peroxisomal matrix proteins, and division of ...
Masanori, Honsho +3 more
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