Results 181 to 190 of about 290,493 (308)

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Mitochondrial Dysfunction in MASLD: Evidence in Dietary Models and Potential Therapeutic Interventions. [PDF]

Biochem Res Int
Villaseñor-Tapia EC, Mendieta-Condado ER, Curiel-Pedraza DA, Reza-Zaldívar EE, Márquez-Aguirre AL.   +4 more
europepmc   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

The Biogenesis of Plant Products. I. The Biogenesis of Rutin.

Chemical and Pharmaceutical Bulletin, 1958
Shibata, Shoji, Yamazaki, Mikio
openaire   +3 more sources

Correction: KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression. [PDF]

Cell Death Dis
Zhang J, Hua C, Zhang Y, Wei P, Tu Y, Wei T.   +5 more
europepmc   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Mechanisms by Which Exercise Delays Brain Aging Through Regulation of the Mitochondrial Quality Control System. [PDF]

Biology (Basel)
Zhu X, Shi L, Dong Y, Sun Y, Jin Q.
europepmc   +1 more source

The Landscape of Exosomes Biogenesis to Clinical Applications

Haitham Al-Madhagi Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, YemenCorrespondence: Haitham Al-Madhagi, Email bio.haitham@tu.edu.yeAbstract: Exosomes are extracellular vesicles that originate from various cells
Al-Madhagi H
core  

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Editor's Note: Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease. [PDF]

Hum Mol Genet
europepmc   +1 more source