Results 181 to 190 of about 439,213 (293)

Table S6 from m⁶A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR

, 2023
Zhe Kong, Yali Lu, Yue Yang, Kun Chang, Yan Lin, Yan Huang, Chenji Wang, Lu Zhang, Wei Xu, Shimin Zhao, Yao Li   +10 more
openalex   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer. [PDF]

Breast Cancer Res
Jouines C, Lo Monaco P, Gaucherot A, Radermecker J, Isaac C, Bourdelais F, Monet MA, Meyer M, Chalabi-Dchar M, Nguyen Van Long F, Baillon L, Froment C, Marcoux J, Vanbelle C, Fenouil T, Durand S, Giraud S, Diaz JJ, Marcel V, Catez F.   +19 more
europepmc   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

Chaperoning mitochondrial biogenesis [PDF]

, 1994
Langer, Thomas, Morimoto, Richard I., Neupert, Walter   +2 more
core  

Pescadillo ribosomal biogenesis factor 1 as a therapeutic target in tumor immunotherapy. [PDF]

World J Gastroenterol
Yu J, Yu B, Ge FL, Ren ZG.
europepmc   +1 more source

P3564Alogliptin, a DPP-4 inhibitor, alleviates atrial remodeling and improves mitochondrial function and biogenesis in diabetic rabbits [PDF]

, 2017
Tonghe Liu, Xinglong Zhang, Z. Zhang, Yongcai Zhao, Ning Jiang, Jiuchun Qiu, Yajuan Yang, Jinze Li, Xue Liang, X. Wang, Gary Tse, G. Li   +11 more
openalex   +1 more source

Suppressing Glycerol‐3‐phosphate Phosphatase and Enhancing Glycerol‐3‐Phosphate Shuttle Flux Crucial for High‐Efficiency Fatty Acid Production in the Fast‐Growing Oleaginous Schizochytrium

Advanced Science, EarlyView.
This study establishes an efficient oleaginous heterotrophic microalga, Schizochytrium, through chassis optimization and metabolic engineering, significantly enhancing fatty acid titers and productivities. It also identifies a regulatory mechanism that coordinates biomass and lipid synthesis, providing a rational target for metabolic pathway rewiring ...
Fangzhong Wang, Weijia Jin, Tiantian Wang, Junkai Ji, Kun Cao, Jianqiang Li, Lei Chen, Weiwen Zhang   +7 more
wiley   +1 more source

Transcriptome-module phenotype association study implicates extracellular vesicles biogenesis in Plasmodium falciparum artemisinin resistance

, 2022
Kwesi Z. Tandoh, Oheneba Charles Kofi Hagan, Michael D. Wilson, Neils B. Quashie, Nancy Odurowah Duah-Quashie   +4 more
openalex   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source