Results 191 to 200 of about 439,213 (293)

Rutin Suppresses EMT and Induces Mitochondrial Biogenesis <i>via</i> ER Stress-linked AMPK/SIRT1 Signaling in Prostate Cancer Cells. [PDF]

Cancer Genomics Proteomics
Chen SH, Wu RC, Huang WL, Wu CH, Mai HC, Yang YL, Hsieh PF, Lin VC, Ou CH.   +8 more
europepmc   +1 more source

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle. [PDF]

J Cachexia Sarcopenia Muscle
Hoolachan JM, Balakrishnan R, McCown EM, Merz KE, Zhou C, Bloom-Saldana E, Fueger PT, Hamilton A, Kiperman T, Ma K, Oh E, Jiang L, Pirrotte P, Shirihai O, Thurmond DC.   +14 more
europepmc   +1 more source

Identification of MIMAS, a multifunctional mega-assembly integrating metabolic and respiratory biogenesis factors of mitochondria [PDF]

Patrick Horten, Kuo Song, Joshua Garlich, Robert Hardt, Lilia Colina-Tenorio, Susanne E. Horvath, Uwe Schulte, Bernd Fakler, Martin van der Laan, Thomas Becker, Rosemary A. Stuart, Nikolaus Pfanner, Heike Rampelt   +12 more
openalex   +1 more source

ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis [PDF]

, 2020
Franziska Eck, Manuel Kaulich, Christian Behrends   +2 more
openalex   +1 more source

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Advanced Science, EarlyView.
Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.
Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu   +13 more
wiley   +1 more source

L-Glutamate enables the EGFR-MEK-ERK-mTFB2 axis to enhance mitochondrial biogenesis in intestinal stem cells. [PDF]

Stem Cell Res Ther
Dou CX, Qu HZ, Qin YC, Wang XF, Zhou JY, Wang XQ, Yan HC.   +6 more
europepmc   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

Establishment of an imaging-based screening pipeline for the identification of human ribosome biogenesis inhibitors. [PDF]

BMC Biol
Gafko C, Hollandi R, Dörner K, Rosellini M, Zemp I, Horvath P, Kutay U.   +6 more
europepmc   +1 more source

Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency [PDF]

, 2009
Verónica T. Cheli, Richard W. Daniels, Ruth Godoy, Diego J. Hoyle, Vasundhara Kandachar, Marta Starcevic, Julián A. Martínez-Agosto, Stephen J. Poole, Aaron DiAntonio, Vett K. Lloyd, Henry C. Chang, David E. Krantz, Esteban C. Dell’Angelica   +12 more
openalex   +1 more source