Results 201 to 210 of about 449,966 (339)

New methods for monitoring mitochondrial biogenesis and mitophagy in vitro and in vivo

, 2017
Jessica A. Williams, Katrina Zhao, Xin Jin, Wen‐Xing Ding   +3 more
openalex   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Altered Expression of Ribosome Biogenesis Regulators (TP53, C-MYC, FBL, and NCL) in Precursor B-cell Acute Lymphoblastic Leukemia and Neuroblastoma. [PDF]

Curr Issues Mol Biol
Horochowska M, Przystupski D, Kamińska M, Bil-Lula I, Kazanowska B, Ussowicz M.   +5 more
europepmc   +1 more source

PTBP1-mediated biogenesis of circATIC promotes progression and cisplatin resistance of bladder cancer [PDF]

Chenchen Huang, Yang Yang, Xiaofei Wang, Shuangchen Chen, Zhifu Liu, Zheng Li, Xingxing Tang, Qian Zhang   +7 more
openalex   +1 more source

Disorders of high‐density lipoprotein biogenesis [PDF]

, 2008
Larbi Krimbou, Isabelle L. Ruel, Zari Dastani, Khalid Al‐Rasadi, Houssein Hajj Hassan, Iulia Iatan, Michel Marcil, Jacques Genest   +7 more
openalex   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Research Progress of Exosome-Derived microRNA in Alcohol Use Disorders: A Critical Review. [PDF]

Addict Biol
Zhang B, Xie TT, Ma Q, Jiang YP, Wang YM.   +4 more
europepmc   +1 more source

The eukaryotic small ribosomal subunit in the context of translational recycling and ribosome biogenesis [PDF]

, 2018
André Heuer
openalex   +1 more source

Additional file 15 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

, 2023
Raquel García-Vílchez, Ana M. Añazco-Guenkova, Sabine Dietmann, Judith López, Virginia Morón-Calvente, Silvia D’Ambrosi, Paz Nombela, Kepa Zamacola, Isabel Mendizabal, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Ianire Astobiza, Sonia Fernández, Alejandro Paniagua, Borja Miguel‐López, Virginie Marchand, Diego Alonso‐López, Angelika Merkel, Ignacio García‐Tuñón, Aitziber Ugalde‐Olano, Ana Loizaga‐Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika González-Lopez, Ana M. Aransay, Tomás Di Domenico, Manuel Sánchez‐Martín, Javier De Las Rivas, Sònia Guil, Yuri Motorin, Mark Helm, Pier Paolo Pandolfi, Arkaitz Carracedo, Sandra Blanco   +36 more
openalex   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source