Results 201 to 210 of about 439,213 (293)

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Inhibition of MARK4 Promotes Mitochondrial Biogenesis by Inducing the Phosphorylation of AMPKα to Reduce Myocardial Damage in Rats With Myocardial Infarction. [PDF]

Cardiol Res Pract
Wu Y, Wang S, Zhang J, Wang W, Zeng Z, Fu L, Li B.   +6 more
europepmc   +1 more source

Relation of Oxidative Stress and Impaired Fibrinolysis with HDL Biogenesis in Indonesian Men with Metabolic Syndrome

, 2010
Ida Paulina Sormin, Widjaja Lukito, Andi Wijaya, Suryani As’ád   +3 more
openalex   +2 more sources

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Dual roles of mTOR in skeletal muscle adaptation: coordinating hypertrophic and mitochondrial biogenesis pathways for exercise-induced chronic disease management. [PDF]

Front Med (Lausanne)
Zhao YC.
europepmc   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Repurposing Doxycycline to Overcome High-Glucose-Induced Mitochondrial Biogenesis-Mediated Chemoresistance in Colorectal Cancer Cells. [PDF]

J Cell Mol Med
Wu CH, Huang CW, Chen YC, Yip KL, Miao ZF, Su WC, Chang TK, Tsai HL, Yeh YS, Liu HS, Wang JY.   +10 more
europepmc   +1 more source

Role of nitric oxide on mitochondrial biogenesis during the ovarian cycle [PDF]

, 2006
Ana Navarro
openalex   +1 more source

Reprogramming Tumor‐Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy

Advanced Science, EarlyView.
This study presents the sono‐sensitive nanorobot Sono@NAT10, which targets NAT10 condensates to reprogram tumor‐associated macrophages in colorectal cancer. By reducing the acetylation level of SRSF2 protein and activating HDAC10, Sono@NAT10 promotes M1 polarization, suppresses tumor progression, and strengthens immunotherapy. The approach demonstrates
Jiahao Zhu, Benjie Xu, Rui Hu, Bo Yang, Peipei Shen, Yu Xu, Xiaojun Zhang, Danqi Qian, Gang Wu, Shengjun Ji, Yutian Zhao, Ke Gu   +11 more
wiley   +1 more source

Complementary Roles of DNA Methylation and miRNA in Regulating Gene Expression Under Environmental Stress in Biological Invasions. [PDF]

Evol Appl
Yan W, Fu R, Huang X, Zhan A.
europepmc   +1 more source