Results 21 to 30 of about 5,403 (178)

Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders [PDF]

, 2014
Background: Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of ELS, utilizing the variable foraging demand (VFD) macaque model, on adolescent ...
Coplan, Jeremy D., Dwork, Andrew J., Fulton, Sasha L., Gorman, Jack M., Hof, Patrick R., Huang, Yung-yu, Jackowski, Andrea Parolin, Kaffman, Arie, Kaufman, Joan, Mann, J. John, Mathew, Sanjay J., Panthangi, Venkatesh, Perera, Tarique D., Reiner, Wade, Tang, Cheuk Y.   +14 more
core   +3 more sources

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]

, 1993
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M., Horowski, R., Kalveram, K. T., Lange, Klaus W., Löschmann, P. A., Riederer, Peter, Sofic, E., Wachtel, H.   +7 more
core   +1 more source

Monoaminergic Orchestration of Motor Programs in a Complex C. elegans Behavior [PDF]

, 2013
Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the animal moves backward and turns ...
Alkema, Mark J., Clark, Christopher M., Donnelly, Jamie L., Francis, Michael M., Haburcak, Marian, Leifer, Andrew M., Pirri, Jennifer K., Samuel, Aravinthan DT   +7 more
core   +4 more sources

HILIC-MS rat brain analysis, a new approach for the study of ischemic attack

Translational Neuroscience, 2017
Clinicians often rely on selected small molecular compounds from body fluids for the detection, screening or monitoring of numerous life-threatening diseases.
Miękus Natalia, Konieczna Lucyna, Kowiański Przemysław, Moryś Janusz, Bączek Tomasz   +4 more
doaj   +1 more source

Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy

Clinics, 2014
A ketogenic diet is an important therapy used in the control of drug-refractory seizures. Many studies have shown that children and adolescents following ketogenic diets exhibit an over 50% reduction in seizure frequency, which is considered to be ...
Patricia Azevedo de Lima, Leticia Pereira de Brito Sampaio, Nágila Raquel Teixeira Damasceno   +2 more
doaj   +1 more source

Disease-specific neuropathological alterations of the locus coeruleus in Alzheimer's disease, Down syndrome, and Parkinson's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The locus coeruleus (LC), the brain's primary source of noradrenaline (NA), undergoes early neurodegeneration in Parkinson's disease (PD), Alzheimer's diseases (AD), and Down syndrome (DS); however, differences have not been examined in parallel.
Fructuoso M, Vermeiren Y, Boluda S, Stimmer L, Crans RAJ, Xicota L, Eisel U, Casan NO, Bun P, Duyckaerts C, Delabar JM, Strydom A, Van Dam D, Dierssen M, De Deyn P, Potier MC.   +15 more
europepmc   +2 more sources

Analysis of Synaptic Proteins in the Cerebrospinal Fluid as a New Tool in the Study of Inborn Errors of Neurotransmission [PDF]

, 2011
In a few rare diseases, specialised studies in cerebrospinal fluid (CSF) are required to identify the underlying metabolic disorder. We aimed to explore the possibility of detecting key synaptic proteins in the CSF, in particular dopaminergic and ...
A García-Cazorla, A García-Cazorla, A García-Cazorla, A Ormazabal, A Rustom, A Zougman, Ana Pérez, Angels García-Cazorla, C Mei De, Carlos Ortez, D Biou, E Thouvenot, EA Bolan, EA Cartier, FA Witzmann, I Corradini, I Marín-Valencia, J Eriksen, JA Kauer, JC Heyden Van Der, KE Sorra, LA Egaña, M Serrano, MA Willemsen, MG Harrington, Rafael Artuch, SB Glickstein, Sofia T. Duarte, TC Südhof, TC Südhof, TJ Volz, TJ Volz   +31 more
core   +1 more source

Characterization of a Putrescine Transaminase From Pseudomonas putida and its Application to the Synthesis of Benzylamine Derivatives

Frontiers in Bioengineering and Biotechnology, 2018
The reductive amination of prochiral ketones using biocatalysts has been of great interest to the pharmaceutical industry in the last decade for integrating novel strategies in the production of chiral building blocks with the intent of minimizing impact
James L. Galman, Deepankar Gahloth, Fabio Parmeggiani, Iustina Slabu, David Leys, Nicholas J. Turner   +5 more
doaj   +1 more source

Mastitis modifies the biogenic amines profile in human milk, with significant changes in the presence of histamine, putrescine and spermine [PDF]

, 2017
Biogenic amines (BAs) are low molecular weight nitrogenous organic compounds with different biological activities. Putrescine, spermidine and spermine are essential for the development of the gut and immune system of newborns, and are all found in human ...
Fernández García, María, Fernández, Leónides, Ladero Losada, Víctor Manuel, Martín, M. Cruz, Pérez, Marta M., Redruello, Begoña, Rodríguez Gómez, Juan M., Río Lagar, Beatriz del, Álvarez González, Miguel Ángel   +8 more
core   +1 more source

Association Between Residential Greenness and Cardiovascular Disease Risk [PDF]

, 2018
Background Exposure to green vegetation has been linked to positive health, but the pathophysiological processes affected by exposure to vegetation remain unclear.
Bhatnagar, Aruni, Conklin, Daniel J., DeFilippis, Andrew, DeJarnett, Natasha, Finch, Jordan, Keith, Rachel J., Krishnasamy, Sathya S., Liu, Gilbert, Lorkiewicz, Pawel, McCracken, James, O'Toole, Timothy E., Rai, Shesh N., Riggs, Daniel W., Srivastava, Sanjay, Tollerud, David J., Wilson, Jeffrey, Xie, Zhengzhi, Yeager, Ray, Zafar, Nagma   +18 more
core   +2 more sources