Results 61 to 70 of about 568 (157)

Larvicidal Activity of Isoflavonoids from Extracts Against

Natural Product Communications, 2012
The biological activity of extracts from the leaves, bark and roots of Muellera frutescens , an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides.
Charlotte Nirma, Alice M S. Rodrigues, Charlie Basset, Lionel Chevolot, Romain Girod, Christian Moretti, Didier Stien, Isabelle Dusfour, Véronique Eparvier   +8 more
doaj   +1 more source

Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics

Pharmaceuticals, 2021
Insulin mimic can promote transporting glucose to muscle tissue and accelerate glucose consumption. It is commonly occurring in many functional foods or traditional medicines.
Xiao-Yue Zhang, Yi-Han Liu, Da-Zhi Liu, Jia-Yang Xu, Qiang Zhang   +4 more
doaj   +1 more source

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas, Igor M. R. Moura, Romário Pereira da Costa, Guilherme Eduardo de Souza, Richele Priscila Severino, Hélder Nagai Consolaro, Luis Felipe de Oliveira, Vinicius Bonatto, Quezia Bezerra Cass, Rafael V. C. Guido, Lorena Ramos Freitas de Sousa   +10 more
wiley   +1 more source

Ellagic Acid Derivatives from Stem Bark: Investigation of their Antiplasmodial Activity

Natural Product Communications, 2009
Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-α-L-2″-acetylrhamnopyranoside, 3-O ...
Claudia A. Simões-Pires, Sandra Vargas, Andrew Marston, Jean-Robert Ioset, Marçal Q. Paulo, An Matheeussen, Louis Maes   +6 more
doaj   +1 more source

Lichen and Its Microbiome as an Untapped Source of Anti‐Biofilm Compounds

Chemistry &Biodiversity, Volume 22, Issue 4, April 17, 2025.
Lichens and their associated fungi give rise to the evaluation of several extracts and compounds against biofilms. ABSTRACT Lichen substances have been first described in the 1870s, and around 10 000 compounds have been isolated and characterized. Most of them have been evaluated for their activity on planktonic microorganisms (bacteria and fungi ...
Marion Millot, Christine Imbert, Christelle Pouget, Marion Girardot, Lengo Mambu   +4 more
wiley   +1 more source

Malformin C preferentially kills glioblastoma stem‐like cells via concerted induction of proteotoxic stress and autophagic flux blockade

Molecular Oncology, Volume 19, Issue 3, Page 785-807, March 2025.
In a fungal extract screen, malformin C was identified as a compound which selectively kills glioblastoma stem‐like cells while sparing normal cells. Malformin C induces proteotoxic stress and disrupts autophagy, exploiting a vulnerability in glioblastoma stem‐like cells.
Emma Phillips, Sizèd van Enk, Sara Kildgaard, Silja Schlue, Mona Göttmann, Victoria Jennings, Frederic Bethke, Gabriele Müller, Christel Herold‐Mende, Daniel Pastor‐Flores, Martin Schneider, Dominic Helm, Thomas Ostenfeld Larsen, Violaine Goidts   +13 more
wiley   +1 more source

Bioguided Fractionation and Isolation of Natural Antidiabetic Agents from Polyherbal Tablet.

INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY
Polyherbal antidiabetic tablets were formulated, evaluated and compressed by combining the powder extract of Nigella sativa, Trigonella foenum, and Glycyrrhiza Glabra. A number of tests were carried out, including a uniformity weight test, an assessment of the tablets’ hardness and friability, an ash value, moisture content, an extractive value that is
Gusti Muhammad Perdana Putera, Vilas B Ghawate, Rahul L Vikhe, Sharvari V Vikhe, Sunayana R Vikhe   +4 more
openaire   +1 more source

The Apoptotic Activity of one VLC Fraction of the Sponge on Human Cervical Cells and the Subsequent Isolation of a Bioactive Polyacetylene

Natural Product Communications, 2013
As part of our ongoing studies on bioactive natural products from marine sponges, we investigated the cytotoxic potential of extracts from the new sponge Petrosia tuberosa sampled from Mauritius waters.
Avin Ramanjooloo, Girish Beedessee, Deepak Arya, Rob WM. vanSoest, Thierry Cresteil, Daniel E.P. Marie   +5 more
doaj   +1 more source

Anti-Inflammatory Effects of 5α,8α-Epidioxycholest-6-en-3β-ol, a Steroidal Endoperoxide Isolated from Aplysia depilans, Based on Bioguided Fractionation and NMR Analysis

Marine Drugs, 2019
Sea hares of Aplysia genus are recognized as a source of a diverse range of metabolites. 5α,8α-Endoperoxides belong to a group of oxidized sterols commonly found in marine organisms and display several bioactivities, including antimicrobial ...
Renato B. Pereira, David M. Pereira, Carlos Jiménez, Jaime Rodríguez, Rosa M. Nieto, Romeu A. Videira, Olga Silva, Paula B. Andrade, Patrícia Valentão   +8 more
doaj   +1 more source

Identification of Minor Secondary Metabolites from the Latex of Croton lechleri (Muell-Arg) and Evaluation of Their Antioxidant Activity

Molecules, 2008
Dragon’s blood (Sangre de drago), a viscous red sap derived from Croton lechleri Muell-Arg (Euphorbiaceae), is extensively used by indigenous cultures of the Amazonian basin for its wound healing properties. The aim of this study was to identify the
Maria Iorizzi, Francesco Visioli, Gelsomina Fico, Sara Vitalini, Franco Zollo, Fulvio Gala, Simona De Marino   +6 more
doaj   +1 more source