FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Community annotation and bioinformatics workforce development in concert--Little Skate Genome Annotation Workshops and Jamborees [PDF]
, 2012 Qi Wang +13 more
openalex +1 more source
Snakemake - a scalable bioinformatics workflow engine
Bioinform., 2018 Johannes Köster, S. Rahmann
semanticscholar +1 more source
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source
STEM enables mapping of single-cell and spatial transcriptomics data with transfer learning
Communications BiologyProfiling spatial variations of cellular composition and transcriptomic characteristics is important for understanding the physiology and pathology of tissues.
Minsheng Hao +10 more
doaj +1 more source
Identification of Bacterial Key Genes and Therapeutic Targets in Hypertensive Patients with Type 2 Diabetes using Bioinformatics Analysis [PDF]
Md. Tahalil Islam Rahat +4 more
openalex +1 more source
Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to
, 2017 Peter D. Kwong +11 more
openalex +1 more source
Bayesian Estimation Improves Prediction of Outcomes After Epilepsy Surgery
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We estimated the statistical power of studies predicting seizure freedom after epilepsy surgery. We extracted data from a Cochrane meta‐analysis. The median power across all studies was 14%. Studies with a median sample size or less (n ≤ 56) and a statistically significant result exaggerated the true effect size by a factor of 5.4, while the ...
Adam S. Dickey +4 more
wiley +1 more source