Results 171 to 180 of about 619,827 (230)

Pathways, outputs and impact of NIH-supported bioinformatics and genomics graduate trainees in Africa. [PDF]

Brief Bioinform
Jjingo D, Walakira A, Hashim S, Cheickna C, Galiwango R, Kibet C, Kivunike FN, Mboowa G, Kakembo FE, Ayodele B, Entfellner JD, de Villiers S, Wambui K, Fatumo S, Chikowore T, Mukisa J, Ssekagiri A, Bbosa N, Mulindwa J, Kyobe S, Nsubuga M, Kebirungi G, Katagirya E, Mwesigwa S, Lujumba I, Kamulegeya R, Kirimunda S, Kanyerezi S, Kiyaga S, Sserwadda I, Kiberu D, Bagaya BS, Okwir J, Nabisubi P, Nabakooza G, Atwine MT, Sserunjogi R, Julius R, Quiñones M, McCarthy M, Cruz P, Noble K, Whalen CJ, Hurt D, Giovanni MY, Tartakovsky M, Ssemwanga D, Kitayimbwa JM, Reynolds SJ, Whalen CC, Kambugu A, Hanchard NA, Jian L, Amoako-Yirenkyi P, Mardon G, Jordan IK, Salifu SP, Wele M, Adebiyi E, Shaffer JG, Doumbia S, Kateete DP, Skelton M, Mulder N, Kayondo JK, Masiga D, H3Africa Consortium.   +66 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

3D dendritic spines shape descriptors for efficient classification and morphology analysis in control and Alzheimer's disease modeling neurons. [PDF]

Bioinformatics
Smirnova D, Ustinova A, Chukanov V, Pchitskaya E.   +3 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Capturing gene-cell duality in a cat's cradle. [PDF]

Bioinformatics
Laddach A, Progatzky F, Pachnis V, Shapiro M.   +3 more
europepmc   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Multi-scale structural similarity embedding search across entire proteomes. [PDF]

Bioinformatics
Segura J, Sanchez-Garcia R, Bittrich S, Rose Y, Burley SK, Duarte JM.   +5 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

CEMUSA: a graph-based integrative metric for evaluating clusters in spatial transcriptomics. [PDF]

Bioinformatics
Hu J, Du Y, Hou S, Ding Y, Li J, Wu H, Sun X.   +6 more
europepmc   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source