Results 191 to 200 of about 615,294 (304)

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Topolow: a mapping algorithm for antigenic cross-reactivity and binding affinity assays. [PDF]

Bioinformatics
Arhami O, Rohani P.
europepmc   +1 more source

Statistical Methods in Bioinformatics: An Introduction [PDF]

, 2002
Jotun Hein
openalex   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

scMGCL: accurate and efficient integration representation of single-cell multi-omics data. [PDF]

Bioinformatics
Cheng Z, Lu R, Zhang S.
europepmc   +1 more source

Bringing the Human Genome and the Revolution in Bioinformatics to the Medical School Classroom

, 2001
Jeffrey A. Magee, Jeffrey I. Gordon, Alison J. Whelan   +2 more
openalex   +1 more source

RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited – bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure [PDF]

, 2002
Janusz M. Bujnicki, Leszek Rychlewski
openalex   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Bridging artificial intelligence and biological sciences: a comprehensive review of large language models in bioinformatics. [PDF]

Brief Bioinform
Lin A, Ye J, Qi C, Zhu L, Mou W, Gan W, Zeng D, Tang B, Xiao M, Chu G, Peng S, Wong HZH, Zhang L, Zhang H, Deng X, Li K, Zhang J, Jiang A, Li Z, Luo P.   +19 more
europepmc   +1 more source

Growth in Bioinformatics [PDF]

, 2002
Chris Sander
openalex   +1 more source