Results 211 to 220 of about 615,294 (304)

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Correction to: Coding genomes with gapped pattern graph convolutional network. [PDF]

Bioinformatics
europepmc   +1 more source

Annotation matters: the effect of structural gene annotation on orthology inference. [PDF]

Bioinformatics
Prieto-Baños S, Nevers Y, Altenhoff A, Warwick Vesztrocy A, Dessimoz C, Glover NM.   +5 more
europepmc   +1 more source

Crystallographer's Challenge in the 21st Century. 3. Frontier of Protein Crystallography. From Genome to Structure: Challenges in Structural Bioinformatics.

, 2001
Kenji Mizuguchi
openalex   +2 more sources

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

PloverDB: a high-performance platform for serving biomedical knowledge graphs as standards-compliant web APIs. [PDF]

Bioinformatics
Glen AK, Deutsch EW, Ramsey SA.
europepmc   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Bioinformatics Becomes Respectable

BioTechniques, 2003
Stuart M. Brown
doaj   +1 more source

PangenePro: an automated pipeline for rapid identification and classification of gene family members. [PDF]

Bioinform Adv
Fatima K, Hu H, Tahir Ul Qamar M.
europepmc   +1 more source

International Conference on Bioinformatics 2002: North–South Networking, 6–8 February 2002, Bangkok, Thailand

, 2001

openalex   +2 more sources