Results 131 to 140 of about 541,804 (167)
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies
Genome BiologyLongitudinal studies are crucial for understanding complex microbiome dynamics and their link to health. We introduce TEMPoral TEnsor Decomposition (TEMPTED), a time-informed dimensionality reduction method for high-dimensional longitudinal data that ...
Pixu Shi +9 more
doaj +1 more source
Bioinformatic Analysis of Cardiac Transcription Networks
, 2011 This work presents the bioinformatic part of an integrative approach to analyze vertebrate cardiac transcription networks. Bioinformatic analyses of a number of high-throughput experiments elucidated regulatory dependencies driving correct spatiotemporal transcription by the interplay between combinatorial transcription factor (TFs) binding and co ...
openaire +3 more sources
Bioinformatics Analysis of -Synuclein [PDF]
Advances in Engineering Research, 2015 Canquan Mao, Damu Wei
openaire +1 more source
Bioinformatics for microbiome analysis
Marine ecosystems harbour a vast microbial diversity which play a crucial role in ecosystemfunctioning. Advancements in DNA sequencing technologies have transformed our ability to analyse microbial populations comprehensively. Metagenomic sequencing has emerged as a pivotal tool for characterising microbial communities across various environments ...
openaire +1 more source