Results 101 to 110 of about 7,581 (247)

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Atomic force microscopy for characterization of decellularized extracellular matrix (dECM) based materials

Science and Technology of Advanced Materials
In live organisms, cells are embedded in tissue-specific extracellular matrix (ECM), which provides chemical and mechanical signals important for cell differentiation, migration, and overall functionality.
Svetlana Batasheva, Svetlana Kotova, Anastasia Frolova, Rawil Fakhrullin   +3 more
doaj   +1 more source

Comparative assessment of volume‐of‐fluid (VOF) multiphase solvers for viscoplastic flow over grooved patterned surfaces

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Accurately simulating multiphase flows at low capillary numbers remains challenging due to spurious currents and interface discretization errors. We present a systematic comparison of four volume‐of‐fluid (VOF) solvers within the OpenFOAM framework for pressure‐driven Poiseuille–Bingham flow over grooved surfaces: interFoam with classical ...
Amir Joulaei, Alice Villette, Seyed Mohammad Taghavi   +2 more
wiley   +1 more source

Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues

, 2019
The regeneration of complex tissues and organs remains a major clinical challenge. With a view towards bioprinting such tissues, we developed a new class of pore-forming bioink to spatially and temporally control the presentation of therapeutic genes ...
Kelly, Daniel, Nicolosi, Valeria
core   +2 more sources

Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

Droplet, EarlyView.
Droplet microfluidics enables precise, versatile fabrication of hydrogel particles with controlled size, composition, and structure. This review summarizes fundamental principles, engineering strategies, and emerging applications, providing a framework for advancing microfluidic hydrogel technologies.
Zhongqiao Gan, Xu Hou
wiley   +1 more source

DeepFreeze 3D‐biofabrication for Bioengineering and Storage of Stem Cells in Thick and Large‐Scale Human Tissue Analogs

Advanced Science
3D bioprinting holds great promise for meeting the increasing need for transplantable tissues and organs. However, slow printing, interlayer mixing, and the extended exposure of cells to non‐physiological conditions in thick structures still hinder ...
Alok Kumar, Robert A. Brown, Daniel Benyamien Roufaeil, Aditi Gupta, Erika L. Lipford, Divya Muthusamy, Amihai Zalzman, Ronna Hertzano, Tao Lowe, Joseph P. Stains, Michal Zalzman   +10 more
doaj   +1 more source

Development of nanocellulose-hyaluronic acid bioinks for 3D bioprinting facial cartilages

Carbohydrate Polymer Technologies and Applications
Nanocellulose (NC) possesses desirable biological and mechanical properties for 3D bioprinting. This study aimed to derive a novel NC-hyaluronic acid (HA) bioink for 3D bioprinting facial cartilages and assess its printability, biocompatibility and ...
Thomas H Jovic, Andrea Gazze, Bethan Morgan, Karl Hawkins, Lewis Francis, Hari Arora, Shareen H Doak, Iain S Whitaker   +7 more
doaj   +1 more source

Bioactive Magnesium Silicate Activating Myocardial Energy Metabolism For Infarcted Myocardium Repair

Exploration, EarlyView.
ABSTRACT The heart is a highly energy‐dependent organ, developing bioenergy‐activating biomaterials to activate myocardial adenosine triphosphate (ATP) production and restore dysregulated energy homeostasis is a promising solution for its functional recovery.
Zhibin Liao, Chen Qin, Erhong Song, Chengbin Ding, Zhixu Wang, Yan Sun, Chen Song, Junjie Liu, Jingge Ma, Hongjian Zhang, Leyu Wang, Chengtie Wu   +11 more
wiley   +1 more source

Bioinspired and Photo-Clickable Thiol-Ene Bioinks for the Extrusion Bioprinting of Mechanically Tunable 3D Skin Models

Biomimetics
Bioinks play a fundamental role in skin bioprinting, dictating the printing fidelity, cell response, and function of bioprinted 3D constructs. However, the range of bioinks that support skin cells’ function and aid in the bioprinting of 3D skin ...
Luís B. Bebiano, Rafaela Presa, Francisca Vieira, Bianca N. Lourenço, Rúben F. Pereira   +4 more
doaj   +1 more source

Freeze‐resistant, conductive semi‐interpenetrating network hydrogels enable oxidative stress regulation and enhanced wound healing

Interdisciplinary Medicine, EarlyView.
A multifunctional SFMA9/PF1 semi‐interpenetrating hydrogel with excellent conductivity, antioxidant activity, and freeze resistance effectively regulates the wound microenvironment, reduces oxidative stress and inflammation, promotes angiogenesis, and accelerates full‐thickness skin regeneration.
Xiaomin Sun, Yanqin Yu, Xinyuan He, Kaiyi Tang, Lijing Teng, Tianbao Qian, Zhu Zeng, Zuquan Hu   +7 more
wiley   +1 more source