Results 51 to 60 of about 3,078 (134)

Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder

Stem Cell Research, 2016
From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assumed to
Abdelkrim Hmadcha, Yolanda Aguilera, Maria Dolores Lozano-Arana, Nuria Mellado, Javier Sánchez, Cristina Moya, Luis Sánchez-Palazón, Jose Palacios, Guillermo Antiñolo, Bernat Soria   +9 more
doaj   +1 more source

NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells

Cells, 2020
The NOTCH family of receptors and ligands is involved in numerous cell differentiation processes, including adipogenesis. We recently showed that overexpression of each of the four NOTCH receptors in 3T3-L1 preadipocytes enhances adipogenesis and ...
María-Milagros Rodríguez-Cano, María-Julia González-Gómez, Beatriz Sánchez-Solana, Eva-María Monsalve, María-José M. Díaz-Guerra, Jorge Laborda, María-Luisa Nueda, Victoriano Baladrón   +7 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

CROSS-ANTAGONISM BETWEEN BMP AND NOTCH SIGNALING AT THE DECISION POINT BETWEEN QUIESCENCE AND ACTIVATION IN ADULT NEURAL STEM CELLS

IBRO Neuroscience Reports, 2023
Pau García-Bolufer, José Manuel Morante-Redolat, Ana Domingo-Muelas, Laura Blasco-Chamarro, Pere Duart-Abadia, Sacri R. Ferrón, Isabel Fariñas   +6 more
doaj   +1 more source

A novel TAp73‐inhibitory compound counteracts stemness features of glioblastoma stem cells

Molecular Oncology
Glioblastoma (GB) is the most common and fatal type of primary malignant brain tumor for which effective therapeutics are still lacking. GB stem cells, with tumor‐initiating and self‐renewal capacity, are mostly responsible for GB malignancy ...
Javier Villoch‐Fernandez, Nicole Martínez‐García, Marta Martín‐López, Laura Maeso‐Alonso, Lorena López‐Ferreras, Alberto Vazquez‐Jimenez, Lisandra Muñoz‐Hidalgo, Noemí Garcia‐Romero, Jose María Sanchez, Antonio Fernandez, Angel Ayuso‐Sacido, Margarita M. Marques, Maria C. Marin   +12 more
doaj   +1 more source

A systematic review of mechanisms of PTEN gene down-regulation mediated by miRNA in prostate cancer

Heliyon
Background: The Phosphatase and Tensin Homolog gene (PTEN) is pivotal in regulating diverse cellular processes, including growth, differentiation, proliferation, and cell survival, mainly by modulating the PI3K/AKT/mTOR pathway.
Fernando Bergez-Hernández, Martín Irigoyen-Arredondo, Alejandra Martínez-Camberos   +2 more
doaj   +1 more source

Enhancing adipose tissue functionality in obesity: senotherapeutics, autophagy and cellular senescence as a target

Biological Research
Obesity, a global health crisis, disrupts multiple systemic processes, contributing to a cascade of metabolic dysfunctions by promoting the pathological expansion of visceral adipose tissue (VAT).
Consuelo Arias, Javiera Álvarez-Indo, Mariana Cifuentes, Eugenia Morselli, Bredford Kerr, Patricia V. Burgos   +5 more
doaj   +1 more source

The expression of immune response genes in patients with chronic Chagas disease is shifted toward the levels observed in healthy subjects as a result of treatment with Benznidazole

Frontiers in Cellular and Infection Microbiology
IntroductionChagas disease, caused by the Trypanosoma cruzi parasite infection, is a potentially life-threatening neglected tropical disease with a worldwide distribution.
Inmaculada Gómez, Adriana Egui, Génesis Palacios, Génesis Palacios, Bartolomé Carrilero, Celia Benítez, Marina Simón, Manuel Segovia, Emma Carmelo, Emma Carmelo, Manuel Carlos López, M. Carmen Thomas   +11 more
doaj   +1 more source

Central carbon metabolism exhibits unique characteristics during the handling of fungal patterns by monocyte-derived dendritic cells

Redox Biology
Monocyte-derived dendritic cells (MDDCs) are key players in the defense against fungal infection because of their outstanding capacity for non-opsonic phagocytosis and phenotypic plasticity.
Yolanda Alvarez, Cristina Mancebo, Sara Alonso, Olimpio Montero, Nieves Fernández, Mariano Sánchez Crespo   +5 more
doaj   +1 more source

Lack of canonical activities of connexins in highly aggressive human prostate cancer cells

Biological Research
Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra- and extra-cellular compartments (hemichannels, HC).
Catalina Asencio, Loreto Véliz, Emilia Flores-Faúndez, Lorena Azócar, Carolina E. Echeverría, Verónica Torres-Estay, Viviana Orellana, Catalina Ramírez-Santelices, Paula Sotomayor, Jorge Cancino, Bredford Kerr, Ainoa Fernandez-Olivares, Mauricio A. Retamal, Juan C. Sáez, Alejandro S. Godoy   +14 more
doaj   +1 more source