Results 31 to 40 of about 3,078 (134)

Anti-P antibodies that impair memory perturb hippocampal glutamatergic receptor trafficking, synapse structure and microglia

Molecular Medicine
Background Anti-ribosomal P protein autoantibodies (anti-P) are associated with psychosis and cognitive dysfunction in patients with systemic lupus erythematosus (SLE), yet the underlying mechanisms remain undefined, hindering targeted therapies.
Nicole Díaz-Valdivia, Mariana Labarca, Claudio Retamal, Sofia Espinoza, Jaime Venegas, Alejandra Catenaccio, Adely de la Peña, Micaela Ricca, Claudia Jara, Daniela Cortés-Díaz, Angela Campos, Francisca Pérez-Molina, Francisca Barake, Bernardita Medel, Cristian Herrera-Cid, Fanny Guzman, Bredford Kerr, Manuel Varas-Godoy, Marcela Bravo-Zehnder, Loreto Massardo, Cheril Tapia-Rojas, Alfonso González   +21 more
doaj   +1 more source

Parasites at the Summit: Unexpected Geographic Distribution of the Blood Parasite Lineage Found in the Endangered Giant Lizard of Tenerife

Integrative Zoology, EarlyView.
We combined microscopic screening and molecular phylogenetic analyses to characterize blood parasites infecting Gallotia intermedia from the coastal cliffs of Montaña de Guaza and to place these infections in a broader biogeographic context. We detected apicomplexan parasites of the genus Karyolysus infecting 53.6% of G.
Rodrigo Megía‐Palma, Gonzalo Albaladejo‐Robles, Gemma Palomar, Javier Martínez, Anamarija Žagar, Alejandro Escánez‐Pérez, Miguel A. Carretero, Wiesław Babik, Santiago Merino   +8 more
wiley   +1 more source

Endogenous Galectin-8 protects against Th17 infiltration and fibrosis following acute kidney injury

Molecular Medicine
Background Acute kidney injury (AKI) is a serious clinical condition characterized by a rapid decline in renal function, often progressing to chronic kidney disease (CKD) and fibrosis.
Elisa Perez-Moreno, Adely de la Peña, Tomás Toledo, Javiera Saez, Francisca Pérez-Molina, Sofía Espinoza, Claudia Metz, Nicole Díaz-Valdivia, Lorena Azócar, Carolina Prado, Rodrigo Pacheco, Fabian Segovia-Miranda, Alejandro S. Godoy, Cristian A. Amador, Teo Feuerhake, Alfonso González, Andrea Soza   +16 more
doaj   +1 more source

GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells

Cells
In this study, we investigated the inter-organelle communication between the Golgi apparatus (GA) and mitochondria. Previous observations suggest that GA-derived vesicles containing phosphatidylinositol 4-phosphate (PI(4)P) play a role in mitochondrial ...
Catalina M. Polanco, Viviana A. Cavieres, Abigail J. Galarza, Claudia Jara, Angie K. Torres, Jorge Cancino, Manuel Varas-Godoy, Patricia V. Burgos, Cheril Tapia-Rojas, Gonzalo A. Mardones   +9 more
doaj   +1 more source

Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes

Aging Cell, Volume 25, Issue 10, October 2026.
Aging induces hyperglucagonemia through direct effects on pancreatic α‐cells or indirect systemic effects. This correlates with increased α‐cell mass as well as various alterations in α‐cell identity and function, which are exacerbated in the context of insulin resistance.
Eva Tudurí, Lucía Almagro, Ana Ojeda‐Rodríguez, Raquel Pascua‐Maestro, Henver S. Brunetta, Sergi Soriano, Alejandro López‐Moreno, Talía Boronat‐Belda, Sergio Velasco‐Avilés, Joel Alves da Silva Junior, Manuel Castellano‐Muñoz, Alex Rafacho, Irene Cózar‐Castellano, Ángel Nadal, Paloma Alonso‐Magdalena, Beatriz Merino, José López‐Miranda, Ivan Quesada   +17 more
wiley   +1 more source

HERPUD1 mediates palmitic acid-induced UPR sustaining TNBC aggressiveness and is destabilized by CK2 pharmacological inhibition

Cell Death and Disease
HERPUD1 is a protein of the endoplasmic reticulum (ER) that is sensitive to the unfolded protein response (UPR) induced during ER stress and has been linked to ER stress tolerance in cancer cells.
Laura Hernández-Torres, Viviana A. Cavieres, Omar Cortés, Eloisa Arias-Muñoz, Francisca Cruzat-Arias, Jorge Catalán-Aguilera, Javiera Álvarez-Indo, Macarena Aguilera-Olguín, Ronny Hernández, Eduardo Silva-Pavez, Julio C. Tapia, Jorge Cancino, Carlos F. Lagos, Tammy P. Pástor, Abigail J. Galarza, Gonzalo A. Mardones, Manuel Varas-Godoy, Nicole Villarreal-Cruz, Franz Villarroel-Espindola, Isabel Saffie, Alfonso González, María José Barrera, Pamela Ehrenfeld, Patricia V. Burgos   +23 more
doaj   +1 more source

Presentación. Las formas sociales de la biociudadanía

Estudios Atacameños, 2019
Este número especial tiene como objetivo aportar a la discusión en torno a la biociudadanía dadas las transformaciones en el campo de la biomedicina en los últimos años y al acrecentamiento de las condiciones sociales que estarían haciendo emerger ...
Andrés G. Seguel, Ximena Zabala
doaj   +1 more source

Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

Frontiers in Cell and Developmental Biology, 2022
Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis.
Lisette Sandoval, Mariana Labarca, Mariana Labarca, Claudio Retamal, Claudio Retamal, Paula Sánchez, Juan Larraín, Alfonso González, Alfonso González, Alfonso González   +9 more
doaj   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, Volume 46, Issue 8, Page 2884-2894, August 2026.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

Cells, 2020
Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Hianara A Bustamante, Karina Cereceda, Alexis E González, Guillermo E Valenzuela, Yorka Cheuquemilla, Sergio Hernández, Eloisa Arias-Muñoz, Cristóbal Cerda-Troncoso, Susanne Bandau, Andrea Soza, Gudrun Kausel, Bredford Kerr, Gonzalo A Mardones, Jorge Cancino, Ronald T Hay, Alejandro Rojas-Fernandez, Patricia V Burgos   +16 more
doaj   +1 more source