Results 11 to 20 of about 3,078 (134)

Quiescence as an Active and Dynamic Regulator of Neural Stem Cells in Adult Olfactory Neurogenesis. [PDF]

Eur J Neurosci
Quiescence in adult neural stem cells is a dynamic, heterogeneous and actively regulated state that integrates intrinsic programs and niche signals. Its modulation across distinct substates governs neurogenesis, aging‐related decline and regenerative potential, reframing quiescence as a central organizer of stem cell function.
Morante-Redolat JM, Fariñas I.
europepmc   +2 more sources

Radiobiology studies of gold nanoparticle-enhanced radiosensitization in proton therapy. [PDF]

Med Phys
Abstract Background Approximately 50%$\%$ of newly diagnosed cancer patients worldwide receive radiotherapy, most commonly with X‐rays. Proton therapy has emerged as a promising alternative, offering complementary advantages over conventional X‐rays due to its highly localized energy deposition at the Bragg peak, thereby reducing radiation exposure to ...
Fuster-Martínez N, Saucedo-Cuberes DH, Jiménez-Ramos MC, Esperante D, Espino JM, Fuster J, Belén-Aguilar JF, González-López L, Huertas P, Jimeno S, Mingarro I, Pascual D, Suárez-García D, García-Murria MJ.   +13 more
europepmc   +2 more sources

Representar e intervenir el comportamiento humano en la era de la tecnobiología

Revista Colombiana de Filosofía de la Ciencia, 2018
En la era de la tecnobiología, los saberes de la biología frecuentemente se presentan al público general como una vía segura y eficiente para modificar comportamientos humanos patológicos o indeseables mediante medios tecnológicos.
Nahuel Pallitto
doaj   +1 more source

Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

Frontiers in Cell and Developmental Biology, 2022
Macroautophagy and the ubiquitin proteasome system work as an interconnected network in the maintenance of cellular homeostasis. Indeed, efficient activation of macroautophagy upon nutritional deprivation is sustained by degradation of preexisting ...
Gabriela Vargas, Omar Cortés, Eloisa Arias-Muñoz, Eloisa Arias-Muñoz, Sergio Hernández, Cristobal Cerda-Troncoso, Laura Hernández, Alexis E. González, Michael H. Tatham, Hianara A. Bustamante, Claudio Retamal, Jorge Cancino, Manuel Varas-Godoy, Ronald T. Hay, Alejandro Rojas-Fernández, Alejandro Rojas-Fernández, Viviana A. Cavieres, Viviana A. Cavieres, Patricia V. Burgos, Patricia V. Burgos, Patricia V. Burgos   +20 more
doaj   +1 more source

Eukaryotic RNA Polymerases: The Many Ways to Transcribe a Gene

Frontiers in Molecular Biosciences, 2021
In eukaryotic cells, three nuclear RNA polymerases (RNA pols) carry out the transcription from DNA to RNA, and they all seem to have evolved from a single enzyme present in the common ancestor with archaea.
Marina Barba-Aliaga, Marina Barba-Aliaga, Paula Alepuz, Paula Alepuz, José E. Pérez-Ortín, José E. Pérez-Ortín   +5 more
doaj   +1 more source

Differential Involvement of Arabidopsis β’-COP Isoforms in Plant Development

Cells, 2022
Coat protein I (COPI) is necessary for intra-Golgi transport and retrograde transport from the Golgi apparatus back to the endoplasmic reticulum. The key component of the COPI coat is the coatomer complex, which is composed of seven subunits (α/β/β’/γ/δ ...
Judit Sánchez-Simarro, Pilar Selvi, César Bernat-Silvestre, Eugenio Gómez Minguet, Fernando Aniento, María Jesús Marcote   +5 more
doaj   +1 more source

TBP and SNAP50 transcription factors bind specifically to the Pr77 promoter sequence from trypanosomatid non-LTR retrotransposons

Parasites & Vectors, 2021
Background Trypanosomatid genomes are colonized by active and inactive mobile DNA elements, such as LINE, SINE-like, SIDER and DIRE retrotransposons. These elements all share a 77-nucleotide-long sequence at their 5′ ends, known as Pr77, which activates ...
Francisco Macías, Raquel Afonso-Lehmann, Patricia E. Carreira, M. Carmen Thomas   +3 more
doaj   +1 more source

KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

Nature Communications, 2019
Inter-organelle signaling coordinates adaptive responses via currently unknown mechanisms. Here, Tapia et al. show that KDEL signaling repositions lysosomes in a complex process termed ‘traffic-induced degradation response for secretion’ (TIDeRS) that ...
Diego Tapia, Tomás Jiménez, Constanza Zamora, Javier Espinoza, Riccardo Rizzo, Alexis González-Cárdenas, Danitza Fuentes, Sergio Hernández, Viviana A. Cavieres, Andrea Soza, Fanny Guzmán, Gloria Arriagada, María Isabel Yuseff, Gonzalo A. Mardones, Patricia V. Burgos, Alberto Luini, Alfonso González, Jorge Cancino   +17 more
doaj   +1 more source

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss

Redox Biology, 2020
Aging is a process characterized by cognitive impairment and mitochondrial dysfunction. In neurons, these organelles are classified as synaptic and non-synaptic mitochondria depending on their localization.
Margrethe A. Olesen, Angie K. Torres, Claudia Jara, Michael P. Murphy, Cheril Tapia-Rojas   +4 more
doaj   +1 more source

Determination of Viability of Human Cartilage Allografts by a Rapid and Quantitative Method Not Requiring Cartilage Digestion

Cell Transplantation, 2008
Fresh osteochondral allograft transplantation is increasingly used for the treatment of cartilage pathologies of the knee. It is believed that transplantation success depends on the presence of viable chondrocytes in the graft, but methods to evaluate ...
Carmen López, Nuria Ajenjo, Maria J. Muñoz-Alonso, Pilar Farde, J. León, J. Gómez-Cimiano   +5 more
doaj   +1 more source