Results 91 to 100 of about 310,970 (312)

Apremilast in the Treatment of Plaque Psoriasis: Differential Use in Psoriasis

Clinical, Cosmetic and Investigational Dermatology, 2022
Jia C Gao,1 Albert G Wu,1 Marissa N Contento,1 Jacqueline M Maher,1 Abigail Cline2 1School of Medicine, New York Medical College, Valhalla, NY, USA; 2Department of Dermatology, New York Medical College, New York, NY, USACorrespondence: Abigail Cline ...
Gao JC, Wu AG, Contento MN, Maher JM, Cline A   +4 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cardiac Sarcoidosis: Clinical Insights, Diagnosis, and Management Strategies

Reviews in Cardiovascular Medicine
Cardiac sarcoidosis (CS) is a multifaceted inflammatory disease that affects the heart, leading to complications such as arrhythmias, heart failure, and sudden cardiac death.
Nicola Farina, Giacomo De Luca, Giovanni Peretto, Alex Bartoli, Antonio Esposito, Marco Matucci-Cerinic, Lorenzo Dagna, Corrado Campochiaro   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma [PDF]

Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.Aim: To elucidate the ...
Tran, Trung N., Fletton, Kirsty, Papadopoulos, Nikolaos G., Brusselle, Guy G., Tsai, Ming-Ju, Wechsler, Michael E., Bosnic-Anticevich, Sinthia Z., Al-Lehebi, Riyad, Denton, Eve, Beastall, Aaron, Pfeffer, Paul E., Fonseca, Joao A., Hansen, Susanne, Larenas-Linnemann, Désirée, Kirenga, Bruce J., Murray, Ruth B., Sadatsafavi, Mohsen, Schleich, Florence, Bourdin, Arnaud, Kuna, Piotr, Christoff, George C., Lehtimäki, Lauri, Chung, Li Ping, Rhee, Chin Kook, Ławkiedraj, Agnieszka, Hew, Mark, Pini, Laura, Hoyte, Flavia, Townend, John, Carter, Victoria, Jackson, David J., Katial, Rohit, Al-Ahmad, Mona, Koh, Mariko Siyue, Porsbjerg, Celeste M., Busby, John, Kostikas, Konstantinos, Nagano, Tatsuya, Katsoulotos, Gregory P., Heaney, Liam G., Hubbard, Richard B., Cano Rosales, Diana Jimena, Amaral, Rita, Cosio, Borja G., Chen, Wenjia, Ulrik, Charlotte Suppli, Bergeron, Celine, Bulathsinhala, Lakmini, Altraja, Alan, Popov, Todor A.   +49 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan

, 2016
Jörg Mahlich,1,2 Rosarin Sruamsiri1,3 1Health Economics, Janssen Pharmaceutical KK, Tokyo, Japan; 2Düsseldorf Institute for Competition Economics (DICE), University of Düsseldorf, Düsseldorf, Germany; 3Center of Pharmaceutical ...
Mahlich J, Sruamsiri R
core  

Biologic Footprint Reconstruction: Rotator Cuff Repair Using Biologic Tuberoplasty

Irreparable rotator cuff tears present significant challenges owing to tear size, tendon retraction, and poor tissue quality. This article describes a surgical approach integrating biologic tuberoplasty with rotator cuff repair, using an acellular human ...
Evan H. Richman, M.D., Daniel J. Stokes, M.D., P. Austin Serbin, M.D., Dylan R. Rakowski, M.D., Katherine A. Burns, M.D., Rachel M. Frank, M.D., Peter B. MacDonald, M.D., F.R.C.S.C.   +6 more
core   +1 more source