Results 111 to 120 of about 302,285 (314)

A systematic review of recent randomized controlled trials for palmoplantar pustulosis

Journal of Dermatological Treatment
Background: Palmoplantar pustulosis (PPP) is a chronic inflammatory condition, that leads to significant functional impairment and reduced quality of life.
Miranda K. Branyiczky, Shahnawaz Towheed, Tiago Torres, Ronald Vender   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Pathophysiology The Biologic Basis for disease in adults and children

, 1994
xliii.;iil.;1577 hal.; 35 ...
Huether Sue E
core  

Pre-biologic assessment of adherence in severe asthma and association with biologic continuation: a UK Severe Asthma Registry Study [PDF]

BackgroundBiologic therapies are approved for uncontrolled severe asthma despite good adherence to inhaled corticosteroids (ICS) and additional controllers.
Gore, Robin, Patel, Pujan, Mansur, Adel H., Pfeffer, Paul, Message, Simon, Mansur, Adel H, Shoaib Faruqi, Adel H Mansur, Ian Pavord, Pfeffer, Paul E., Shamsa Naveed, Paul Dilworth, Pantin, Thomas, Pavord, Ian, Rekha Chaudhuri, Deepak Subramanian, David Jackson, Rupani, Hitasha, Vyas, Aashish, Heaney, Liam, Hitasha Rupani, Dodd, James William, Hassan Burhan, Murphy, Anna Claire, Siddiqui, Salman, Matthew Masoli, ?, ?, Martin Doherty, Patel, Mitesh, Faruqi, Shoaib, Heaney, Liam G, Bloom, Chloe I, McDowell, Ronald, Chaudhuri, Rekha, John Busby, Burhan, Hassan, Thomas Brown, Masoli, Matthew, Naveed, Shamsa, Subramanian, Deepak, Sammut, David, Anna Claire Murphy, Chloe I Bloom, Freda Yang, Yang, Freda, Busby, John, Dodd, James, Salman Siddiqui, David Sammut, Heaney, Liam G., Murphy, Anna, Elfatih Idris, Bloom, Chloe, Jackson, David, Idris, Elfatih, Simon Message, Pujan H Patel, Patel, Pujan H., Bloom, Chloe I., Ronald McDowell, Sherif Gonem, Robert Stone, Mitesh Patel, Patel, Pujan H, Aashish Vyas, Pavord, Ian D, Brown, Thomas, Pfeffer, Paul E, Thomas Pantin, Liam G Heaney, Robin Gore, James William Dodd   +71 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Biologic Therapies: From Complexity to Clinical Practice in a Changing Environment [PDF]

, 2015
This symposium provided an opportunity for global experts to discuss the challenges posed by the introduction of biosimilars. The impact of the manufacturing process on clinical outcomes, maintaining treatment responses over the long term, and issues ...
Brian Feagan, Geert D’Haens, Remo Panaccione   +2 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Biologic targeting in the treatment of inflammatory bowel diseases [Retraction]

, 2014
Bosani M, Ardizzone S, Porro GB. Biologics: Targets and Therapy. 2009;3:77–97.This paper has been retracted after we were made aware that it contains a large amount of reused, and uncited material that was not placed within quotation marks.The ...
Ardizzone S, Porro GB, Bosani M
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Openness to and preference for attributes of biologic therapy prior to initiation among patients with rheumatoid arthritis: patient and rheumatologist perspectives and implications for decision making

, 2016
Susan C Bolge,1 Amir Goren,2 Duncan Brown,2 Seth Ginsberg,3 Isabel Allen4 1Health Economics & Outcomes Research, Janssen Scientific Affairs, LLC, Raritan, NJ, 2Health Outcomes Practice, Kantar Health, New York, 3Global Healthy Living Foundation ...
Allen I, Bolge SC, Brown D, Goren A, Ginsberg S   +4 more
core