Results 131 to 140 of about 302,285 (314)

‘Biological Signals’ to ‘Biological Signals and Receptors’

Neurosignals, 1998
Pang, SF, Ward, PA, Cardinali, DP
openaire   +4 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Indication for biologic treatment in a real-world cohort of chronic rhinosinusitis patients according to international recommendations: Evidence from the European CRS outcome registry (CHRINOSOR)

World Allergy Organization Journal
Background: In recent years, treatment options for patients with uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) have been expanded with biologics.
Sven F. Seys, PhD, Josje J. Otten, MD, PhD, Joost de Kinderen, MBA, Giulia Bettio, MSc, Alexandros Andrianakis, MD, Isam Alobid, MD, Carlo Cavaliere, MD, Peter W. Hellings, MD, PhD, Laura Van Gerven, MD, PhD, Valérie Hox, MD, PhD, Claire Hopkins, MD, PhD, Anette Kjeldsen, MD, PhD, Sven Schneider, MD, PhD, Peter-Valentin Tomazic, MD, PhD, Zuzana Diamant, MD, PhD, Julia Eckl-Dorna, MD, PhD, Wytske J. Fokkens, MD, PhD, Clemens Holzmeister, MD, Kenneth Larsen, MD, Anu Laulajainen-Hongisto, MD, PhD, Valerie Lund, MD, PhD, Gert Mariën, MSc, Simonetta Masieri, MD, PhD, Geoffrey Mortuaire, MD, PhD, Mathilde Moyaert, MD, Joaquim Mullol, MD, Camilo Rodriguez van Strahlen, MD, Marco de Vincentiis, MD, PhD, Martin Wagenmann, MD, PhD, Sietze Reitsma, MD, PhD, Claus Bachert, MD, PhD   +30 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prescribing Biologic Immune-Modifying Therapies for Patients with a History of Cancer: A Cross-Specialty Review

Current Oncology
The rapid expansion of biologic therapies for immune-mediated inflammatory diseases has raised significant clinical concerns regarding malignancy risk, particularly for patients with a history of cancer.
Stephanie Bowe, Seamus O’Reilly, Michelle Murphy, Anne O’Mahony, Sinead Harney, Akbar Zulquernain, John Bourke   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis [PDF]

Ling Ma, Xiaoli Chen, Mohammed Ali Ali Aziz, Aijun Chen, Tao Cai, Shuang Chen Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Tao Cai, Department of ...
Chen A, Cai T, Ma L, Chen X, Chen S, Aziz MAA   +5 more
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