Results 141 to 150 of about 310,970 (312)
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira +2 morewiley +1 more sourceBiologic markers and antidepressant response
, 1983 The use of biologic markers to predict antidepressant treatment response may lead to more rational selection of specific drugs for individual patients. Several biologic markers being developed as potential predictors of antidepressant treatment response ...Okonek, A., Ostrow, D. G., Gibbons, R., Davis, J. M., Cooper, R. +4 morecore Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...Leonardo Andreoni, Alberto Crediwiley +1 more sourceTable_3_Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma.docx
BackgroundTo date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.AimTo elucidate the ...Sinthia Z. Bosnic-Anticevich (18408009), Ruth B. Murray (9263969), Andrew N. Menzies-Gow (18408036), George C. Christoff (18408000), Christian Taube (35629), Ivan Solarte (18408048), Laura Pini (10969333), Tze Lee Tan (18408066), Sundeep Salvi (804859), Luisa Brussino (6617354), Eve Denton (18408024), Carlos A. Torres-Duque (11136750), Richard B. Hubbard (7777829), Bassam Mahboub (7362143), Giorgio Walter Canonica (7382129), Rita Amaral (5173736), Lauri Lehtimäki (689957), Trung N. Tran (5559110), Mei Fong Liew (10909834), John Townend (118565), Joao A. Fonseca (18408027), Eileen Wang (4471834), Camille Taillé (829699), Celeste M. Porsbjerg (9263975), Borja G. Cosio (3184737), Diahn-Warng Perng (Steve) (18408060), Alan Altraja (74156), Mark Hew (3203178), Tatsuya Nagano (636701), Guy G. Brusselle (7634108), Celine Bergeron (18407997), Désirée Larenas-Linnemann (12113454), David B. Price (3133764), David J. Jackson (4405432), Mona Al-Ahmad (12040516), Lakmini Bulathsinhala (3663172), Chau-Chyun Sheu (524362), Chin Kook Rhee (7492325), Kirsty Fletton (18408015), Enrico Heffler (6617369), Leif Bjermer (3291531), Bellanid Rodríguez-Cáceres (18408045), Stefania Nicola (6851225), Agnieszka Ławkiedraj (18408033), Neil Martin (73632), Luis Perez-De-Llano (18408042), John Busby (3509471), Mohsen Sadatsafavi (63962), John Abisheganaden (14581367), Nikolaos G. Papadopoulos (7677542), Tunn Ren Tay (3203172), Gregory P. Katsoulotos (18408003), Flavia Hoyte (18408030), Ming-Ju Tsai (770331), Michael E. Wechsler (7923218), Martina Zappa (18408051), Susanne Hansen (323324), Liam G. Heaney (7754321), Victoria Carter (232149), Jorge Máspero (18408057), Aaron Beastall (18408012), Peter G. Gibson (8250825), Wenjia Chen (844791), Li Ping Chung (18408021), Konstantinos Kostikas (361271), Charlotte Suppli Ulrik (7757765), Richard W. Costello (7934465), Riyad Al-Lehebi (18408006), Piotr Kuna (3549902), Arnaud Bourdin (376853), Takashi Iwanaga (2166256), Libardo Jiménez-Maldonado (18408069), Concetta Sirena (18408063), Paul E. Pfeffer (4984613), Bruce J. Kirenga (8823890), Pee Hwee Pang (7724246), Matthew J. Peters (8781407), Francesca Puggioni (6851219), Todor A. Popov (7583747), Pujan H. Patel (18408039), Luisa Ricciardi (12532573), Rohit Katial (12542123), Andriana I. Papaioannou (13531845), Diana Jimena Cano Rosales (18408018), Karin Dahl Assing (18408054), Florence Schleich (394436), Mariko Siyue Koh (9295747) +86 morecore +1 more sourceTable_2_Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma.docx
BackgroundTo date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.AimTo elucidate the ...Sinthia Z. Bosnic-Anticevich (18408009), Ruth B. Murray (9263969), Andrew N. Menzies-Gow (18408036), George C. Christoff (18408000), Christian Taube (35629), Ivan Solarte (18408048), Laura Pini (10969333), Tze Lee Tan (18408066), Sundeep Salvi (804859), Luisa Brussino (6617354), Eve Denton (18408024), Carlos A. Torres-Duque (11136750), Richard B. Hubbard (7777829), Bassam Mahboub (7362143), Giorgio Walter Canonica (7382129), Rita Amaral (5173736), Lauri Lehtimäki (689957), Trung N. Tran (5559110), Mei Fong Liew (10909834), John Townend (118565), Joao A. Fonseca (18408027), Eileen Wang (4471834), Camille Taillé (829699), Celeste M. Porsbjerg (9263975), Borja G. Cosio (3184737), Diahn-Warng Perng (Steve) (18408060), Alan Altraja (74156), Mark Hew (3203178), Tatsuya Nagano (636701), Guy G. Brusselle (7634108), Celine Bergeron (18407997), Désirée Larenas-Linnemann (12113454), David B. Price (3133764), David J. Jackson (4405432), Mona Al-Ahmad (12040516), Lakmini Bulathsinhala (3663172), Chau-Chyun Sheu (524362), Chin Kook Rhee (7492325), Kirsty Fletton (18408015), Enrico Heffler (6617369), Leif Bjermer (3291531), Bellanid Rodríguez-Cáceres (18408045), Stefania Nicola (6851225), Agnieszka Ławkiedraj (18408033), Neil Martin (73632), Luis Perez-De-Llano (18408042), John Busby (3509471), Mohsen Sadatsafavi (63962), John Abisheganaden (14581367), Nikolaos G. Papadopoulos (7677542), Tunn Ren Tay (3203172), Gregory P. Katsoulotos (18408003), Flavia Hoyte (18408030), Ming-Ju Tsai (770331), Michael E. Wechsler (7923218), Martina Zappa (18408051), Susanne Hansen (323324), Liam G. Heaney (7754321), Victoria Carter (232149), Jorge Máspero (18408057), Aaron Beastall (18408012), Peter G. Gibson (8250825), Wenjia Chen (844791), Li Ping Chung (18408021), Konstantinos Kostikas (361271), Charlotte Suppli Ulrik (7757765), Richard W. Costello (7934465), Riyad Al-Lehebi (18408006), Piotr Kuna (3549902), Arnaud Bourdin (376853), Takashi Iwanaga (2166256), Libardo Jiménez-Maldonado (18408069), Concetta Sirena (18408063), Paul E. Pfeffer (4984613), Bruce J. Kirenga (8823890), Pee Hwee Pang (7724246), Matthew J. Peters (8781407), Francesca Puggioni (6851219), Todor A. Popov (7583747), Pujan H. Patel (18408039), Luisa Ricciardi (12532573), Rohit Katial (12542123), Andriana I. Papaioannou (13531845), Diana Jimena Cano Rosales (18408018), Karin Dahl Assing (18408054), Florence Schleich (394436), Mariko Siyue Koh (9295747) +86 morecore +1 more sourceLeucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far +7 morewiley +1 more sourceCombining biologic and phototherapy treatments for psoriasis: safety, efficacy, and patient acceptability
, 2016 Benjamin Farahnik,1 Viraat Patel,2 Kourosh Beroukhim,3 Tian Hao Zhu,4 Michael Abrouk,2 Mio Nakamura,5 Rasnik Singh,3 Kristina Lee,5 Tina Bhutani,5 John Koo5 1University of Vermont College of Medicine, Burlington, VT; 2School of Medicine, University of ...Koo J, Nakamura M, Beroukhim K, Farahnik B, Lee K, Patel V, Abrouk M, Singh R, Zhu TH, Bhutani T +9 morecore Table_5_Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma.docx
BackgroundTo date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.AimTo elucidate the ...Sinthia Z. Bosnic-Anticevich (18408009), Ruth B. Murray (9263969), Andrew N. Menzies-Gow (18408036), George C. Christoff (18408000), Christian Taube (35629), Ivan Solarte (18408048), Laura Pini (10969333), Tze Lee Tan (18408066), Sundeep Salvi (804859), Luisa Brussino (6617354), Eve Denton (18408024), Carlos A. Torres-Duque (11136750), Richard B. Hubbard (7777829), Bassam Mahboub (7362143), Giorgio Walter Canonica (7382129), Rita Amaral (5173736), Lauri Lehtimäki (689957), Trung N. Tran (5559110), Mei Fong Liew (10909834), John Townend (118565), Joao A. Fonseca (18408027), Eileen Wang (4471834), Camille Taillé (829699), Celeste M. Porsbjerg (9263975), Borja G. Cosio (3184737), Diahn-Warng Perng (Steve) (18408060), Alan Altraja (74156), Mark Hew (3203178), Tatsuya Nagano (636701), Guy G. Brusselle (7634108), Celine Bergeron (18407997), Désirée Larenas-Linnemann (12113454), David B. Price (3133764), David J. Jackson (4405432), Mona Al-Ahmad (12040516), Lakmini Bulathsinhala (3663172), Chau-Chyun Sheu (524362), Chin Kook Rhee (7492325), Kirsty Fletton (18408015), Enrico Heffler (6617369), Leif Bjermer (3291531), Bellanid Rodríguez-Cáceres (18408045), Stefania Nicola (6851225), Agnieszka Ławkiedraj (18408033), Neil Martin (73632), Luis Perez-De-Llano (18408042), John Busby (3509471), Mohsen Sadatsafavi (63962), John Abisheganaden (14581367), Nikolaos G. Papadopoulos (7677542), Tunn Ren Tay (3203172), Gregory P. Katsoulotos (18408003), Flavia Hoyte (18408030), Ming-Ju Tsai (770331), Michael E. Wechsler (7923218), Martina Zappa (18408051), Susanne Hansen (323324), Liam G. Heaney (7754321), Victoria Carter (232149), Jorge Máspero (18408057), Aaron Beastall (18408012), Peter G. Gibson (8250825), Wenjia Chen (844791), Li Ping Chung (18408021), Konstantinos Kostikas (361271), Charlotte Suppli Ulrik (7757765), Richard W. Costello (7934465), Riyad Al-Lehebi (18408006), Piotr Kuna (3549902), Arnaud Bourdin (376853), Takashi Iwanaga (2166256), Libardo Jiménez-Maldonado (18408069), Concetta Sirena (18408063), Paul E. Pfeffer (4984613), Bruce J. Kirenga (8823890), Pee Hwee Pang (7724246), Matthew J. Peters (8781407), Francesca Puggioni (6851219), Todor A. Popov (7583747), Pujan H. Patel (18408039), Luisa Ricciardi (12532573), Rohit Katial (12542123), Andriana I. Papaioannou (13531845), Diana Jimena Cano Rosales (18408018), Karin Dahl Assing (18408054), Florence Schleich (394436), Mariko Siyue Koh (9295747) +86 morecore +1 more sourceA context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos +9 morewiley +1 more source
