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Table_7_Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma.docx
BackgroundTo date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.AimTo elucidate the ...Sinthia Z. Bosnic-Anticevich (18408009), Ruth B. Murray (9263969), Andrew N. Menzies-Gow (18408036), George C. Christoff (18408000), Christian Taube (35629), Ivan Solarte (18408048), Laura Pini (10969333), Tze Lee Tan (18408066), Sundeep Salvi (804859), Luisa Brussino (6617354), Eve Denton (18408024), Carlos A. Torres-Duque (11136750), Richard B. Hubbard (7777829), Bassam Mahboub (7362143), Giorgio Walter Canonica (7382129), Rita Amaral (5173736), Lauri Lehtimäki (689957), Trung N. Tran (5559110), Mei Fong Liew (10909834), John Townend (118565), Joao A. Fonseca (18408027), Eileen Wang (4471834), Camille Taillé (829699), Celeste M. Porsbjerg (9263975), Borja G. Cosio (3184737), Diahn-Warng Perng (Steve) (18408060), Alan Altraja (74156), Mark Hew (3203178), Tatsuya Nagano (636701), Guy G. Brusselle (7634108), Celine Bergeron (18407997), Désirée Larenas-Linnemann (12113454), David B. Price (3133764), David J. Jackson (4405432), Mona Al-Ahmad (12040516), Lakmini Bulathsinhala (3663172), Chau-Chyun Sheu (524362), Chin Kook Rhee (7492325), Kirsty Fletton (18408015), Enrico Heffler (6617369), Leif Bjermer (3291531), Bellanid Rodríguez-Cáceres (18408045), Stefania Nicola (6851225), Agnieszka Ławkiedraj (18408033), Neil Martin (73632), Luis Perez-De-Llano (18408042), John Busby (3509471), Mohsen Sadatsafavi (63962), John Abisheganaden (14581367), Nikolaos G. Papadopoulos (7677542), Tunn Ren Tay (3203172), Gregory P. Katsoulotos (18408003), Flavia Hoyte (18408030), Ming-Ju Tsai (770331), Michael E. Wechsler (7923218), Martina Zappa (18408051), Susanne Hansen (323324), Liam G. Heaney (7754321), Victoria Carter (232149), Jorge Máspero (18408057), Aaron Beastall (18408012), Peter G. Gibson (8250825), Wenjia Chen (844791), Li Ping Chung (18408021), Konstantinos Kostikas (361271), Charlotte Suppli Ulrik (7757765), Richard W. Costello (7934465), Riyad Al-Lehebi (18408006), Piotr Kuna (3549902), Arnaud Bourdin (376853), Takashi Iwanaga (2166256), Libardo Jiménez-Maldonado (18408069), Concetta Sirena (18408063), Paul E. Pfeffer (4984613), Bruce J. Kirenga (8823890), Pee Hwee Pang (7724246), Matthew J. Peters (8781407), Francesca Puggioni (6851219), Todor A. Popov (7583747), Pujan H. Patel (18408039), Luisa Ricciardi (12532573), Rohit Katial (12542123), Andriana I. Papaioannou (13531845), Diana Jimena Cano Rosales (18408018), Karin Dahl Assing (18408054), Florence Schleich (394436), Mariko Siyue Koh (9295747) +86 morecore +1 more sourceIndication for biologic treatment in a real-world cohort of chronic rhinosinusitis patients according to international recommendations: Evidence from the European CRS outcome registry (CHRINOSOR)
World Allergy Organization JournalBackground: In recent years, treatment options for patients with uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) have been expanded with biologics.Sven F. Seys, PhD, Josje J. Otten, MD, PhD, Joost de Kinderen, MBA, Giulia Bettio, MSc, Alexandros Andrianakis, MD, Isam Alobid, MD, Carlo Cavaliere, MD, Peter W. Hellings, MD, PhD, Laura Van Gerven, MD, PhD, Valérie Hox, MD, PhD, Claire Hopkins, MD, PhD, Anette Kjeldsen, MD, PhD, Sven Schneider, MD, PhD, Peter-Valentin Tomazic, MD, PhD, Zuzana Diamant, MD, PhD, Julia Eckl-Dorna, MD, PhD, Wytske J. Fokkens, MD, PhD, Clemens Holzmeister, MD, Kenneth Larsen, MD, Anu Laulajainen-Hongisto, MD, PhD, Valerie Lund, MD, PhD, Gert Mariën, MSc, Simonetta Masieri, MD, PhD, Geoffrey Mortuaire, MD, PhD, Mathilde Moyaert, MD, Joaquim Mullol, MD, Camilo Rodriguez van Strahlen, MD, Marco de Vincentiis, MD, PhD, Martin Wagenmann, MD, PhD, Sietze Reitsma, MD, PhD, Claus Bachert, MD, PhD +30 moredoaj +1 more sourceTranslophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura +11 morewiley +1 more sourcePersonalization of biologic therapy in patients with rheumatoid arthritis: less frequently accounted choice-driving variables
, 2018 Laura Niccoli,1 Carlotta Nannini,1 Corrado Blandizzi,2 Stefania Mantarro,2 Marta Mosca,3 Ombretta Di Munno,3 Delia Goletti,4 Maurizio Benucci,5 Francesca Li Gobbi,5 Emanuele Cassarà,1 Olga Kaloudi,1 Fabrizio Cantini1 1Department of ...Mantarro S, Mosca M, Niccoli L, Cantini F, Cassarà E, Li Gobbi F, Kaloudi O, Di Munno O, Goletti D, Nannini C, Blandizzi C, Benucci M +11 morecore Table_4_Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma.docx
BackgroundTo date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.AimTo elucidate the ...Sinthia Z. Bosnic-Anticevich (18408009), Ruth B. Murray (9263969), Andrew N. Menzies-Gow (18408036), George C. Christoff (18408000), Christian Taube (35629), Ivan Solarte (18408048), Laura Pini (10969333), Tze Lee Tan (18408066), Sundeep Salvi (804859), Luisa Brussino (6617354), Eve Denton (18408024), Carlos A. Torres-Duque (11136750), Richard B. Hubbard (7777829), Bassam Mahboub (7362143), Giorgio Walter Canonica (7382129), Rita Amaral (5173736), Lauri Lehtimäki (689957), Trung N. Tran (5559110), Mei Fong Liew (10909834), John Townend (118565), Joao A. Fonseca (18408027), Eileen Wang (4471834), Camille Taillé (829699), Celeste M. Porsbjerg (9263975), Borja G. Cosio (3184737), Diahn-Warng Perng (Steve) (18408060), Alan Altraja (74156), Mark Hew (3203178), Tatsuya Nagano (636701), Guy G. Brusselle (7634108), Celine Bergeron (18407997), Désirée Larenas-Linnemann (12113454), David B. Price (3133764), David J. Jackson (4405432), Mona Al-Ahmad (12040516), Lakmini Bulathsinhala (3663172), Chau-Chyun Sheu (524362), Chin Kook Rhee (7492325), Kirsty Fletton (18408015), Enrico Heffler (6617369), Leif Bjermer (3291531), Bellanid Rodríguez-Cáceres (18408045), Stefania Nicola (6851225), Agnieszka Ławkiedraj (18408033), Neil Martin (73632), Luis Perez-De-Llano (18408042), John Busby (3509471), Mohsen Sadatsafavi (63962), John Abisheganaden (14581367), Nikolaos G. Papadopoulos (7677542), Tunn Ren Tay (3203172), Gregory P. Katsoulotos (18408003), Flavia Hoyte (18408030), Ming-Ju Tsai (770331), Michael E. Wechsler (7923218), Martina Zappa (18408051), Susanne Hansen (323324), Liam G. Heaney (7754321), Victoria Carter (232149), Jorge Máspero (18408057), Aaron Beastall (18408012), Peter G. Gibson (8250825), Wenjia Chen (844791), Li Ping Chung (18408021), Konstantinos Kostikas (361271), Charlotte Suppli Ulrik (7757765), Richard W. Costello (7934465), Riyad Al-Lehebi (18408006), Piotr Kuna (3549902), Arnaud Bourdin (376853), Takashi Iwanaga (2166256), Libardo Jiménez-Maldonado (18408069), Concetta Sirena (18408063), Paul E. Pfeffer (4984613), Bruce J. Kirenga (8823890), Pee Hwee Pang (7724246), Matthew J. Peters (8781407), Francesca Puggioni (6851219), Todor A. Popov (7583747), Pujan H. Patel (18408039), Luisa Ricciardi (12532573), Rohit Katial (12542123), Andriana I. Papaioannou (13531845), Diana Jimena Cano Rosales (18408018), Karin Dahl Assing (18408054), Florence Schleich (394436), Mariko Siyue Koh (9295747) +86 morecore +1 more sourceBiologic agents in psoriasis
, 2008 Psoriasis is a chronic, inflammatory disease affecting 1-3% of population. Advances in the pathogenesis of psoriasis and biotechnology have led to the development of targeted therapy named biologic agents.core Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov +3 morewiley +1 more sourceTable_6_Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma.docx
BackgroundTo date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.AimTo elucidate the ...Sinthia Z. Bosnic-Anticevich (18408009), Ruth B. Murray (9263969), Andrew N. Menzies-Gow (18408036), George C. Christoff (18408000), Christian Taube (35629), Ivan Solarte (18408048), Laura Pini (10969333), Tze Lee Tan (18408066), Sundeep Salvi (804859), Luisa Brussino (6617354), Eve Denton (18408024), Carlos A. Torres-Duque (11136750), Richard B. Hubbard (7777829), Bassam Mahboub (7362143), Giorgio Walter Canonica (7382129), Rita Amaral (5173736), Lauri Lehtimäki (689957), Trung N. Tran (5559110), Mei Fong Liew (10909834), John Townend (118565), Joao A. Fonseca (18408027), Eileen Wang (4471834), Camille Taillé (829699), Celeste M. Porsbjerg (9263975), Borja G. Cosio (3184737), Diahn-Warng Perng (Steve) (18408060), Alan Altraja (74156), Mark Hew (3203178), Tatsuya Nagano (636701), Guy G. Brusselle (7634108), Celine Bergeron (18407997), Désirée Larenas-Linnemann (12113454), David B. Price (3133764), David J. Jackson (4405432), Mona Al-Ahmad (12040516), Lakmini Bulathsinhala (3663172), Chau-Chyun Sheu (524362), Chin Kook Rhee (7492325), Kirsty Fletton (18408015), Enrico Heffler (6617369), Leif Bjermer (3291531), Bellanid Rodríguez-Cáceres (18408045), Stefania Nicola (6851225), Agnieszka Ławkiedraj (18408033), Neil Martin (73632), Luis Perez-De-Llano (18408042), John Busby (3509471), Mohsen Sadatsafavi (63962), John Abisheganaden (14581367), Nikolaos G. Papadopoulos (7677542), Tunn Ren Tay (3203172), Gregory P. Katsoulotos (18408003), Flavia Hoyte (18408030), Ming-Ju Tsai (770331), Michael E. Wechsler (7923218), Martina Zappa (18408051), Susanne Hansen (323324), Liam G. Heaney (7754321), Victoria Carter (232149), Jorge Máspero (18408057), Aaron Beastall (18408012), Peter G. Gibson (8250825), Wenjia Chen (844791), Li Ping Chung (18408021), Konstantinos Kostikas (361271), Charlotte Suppli Ulrik (7757765), Richard W. Costello (7934465), Riyad Al-Lehebi (18408006), Piotr Kuna (3549902), Arnaud Bourdin (376853), Takashi Iwanaga (2166256), Libardo Jiménez-Maldonado (18408069), Concetta Sirena (18408063), Paul E. Pfeffer (4984613), Bruce J. Kirenga (8823890), Pee Hwee Pang (7724246), Matthew J. Peters (8781407), Francesca Puggioni (6851219), Todor A. Popov (7583747), Pujan H. Patel (18408039), Luisa Ricciardi (12532573), Rohit Katial (12542123), Andriana I. Papaioannou (13531845), Diana Jimena Cano Rosales (18408018), Karin Dahl Assing (18408054), Florence Schleich (394436), Mariko Siyue Koh (9295747) +86 morecore +1 more sourceAdverse reactions to biologic agents and their medical management
, 2014 Biologic agents have substantially advanced the treatment of immunological disorders, including chronic inflammatory and autoimmune diseases. However, these drugs are often associated with adverse events (AEs), including allergic, immunological and other Comte, Denis, Boyman, Onur, Spertini, F., Boyman, O., Comte, D., Spertini, François, Boyman O, Comte D, Spertini F +8 morecore +1 more source
