Results 121 to 130 of about 302,285 (314)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Assessment and monitoring of biologic drug adverse events in patients with psoriasis
, 2016 Tessa Hanley, Marc Handford, Dawn Lavery, Zenas ZN Yiu Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester, UKBackground: Current treatment guidelines for biologic therapies in psoriasis differ in their recommendation for the monitoring of
Handford M, Hanley T, Lavery D, Yiu ZZN
core
Designing biologic selectivity for inflammatory bowel disease – role of vedolizumab [PDF]
, 2014 Niklas Krupka, Daniel C Baumgart Division of Gastroenterology and Hepatology, Department of Medicine, Charité Medical School, Humboldt-University of Berlin, Berlin, Germany Abstract: Crohn’s disease and ulcerative colitis are two chronic ...
Krupka N, Baumgart DC
core
Biologic Interaction and Their Identification [PDF]
, 2006 The definitions of a biologic interaction and causal interdependence are reconsidered in light of a sufficient-component cause framework. Various conditions and statistical tests are derived for the presence of biologic interactions.
Robins, James, VanderWeele, Tyler J
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Influence of Emphysema on Treatment Response to Biologic Therapy in Severe Asthma [PDF]
Leonie Biener,1,* Hussein Morobeid,1,* Carmen Pizarro,1 Daniel Kuetting,2 Georg Nickenig,1 Dirk Skowasch1 1Department of Internal Medicine II – Cardiology, Pneumology, Angiology, University Hospital of Bonn, Bonn, Germany; 2Department of ...
Skowasch D +5 more
core
Psoriasis: Targets and TherapyAlim Osman, Alexandra Nigro, Amanda Chen Taylor, Ryan Saal, Ana Ormaza Vera, Clinton Enos Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA, USACorrespondence: Alim Osman, Department of Dermatology, Eastern Virginia Medical School ...
Osman A +5 more
doaj
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
, 2008 Psoriasis is a chronic, inflammatory disease affecting 1-3% of population. Advances in the pathogenesis of psoriasis and biotechnology have led to the development of targeted therapy named biologic agents.
core
Biologic Footprint Reconstruction: Rotator Cuff Repair Using Biologic Tuberoplasty
Irreparable rotator cuff tears present significant challenges owing to tear size, tendon retraction, and poor tissue quality. This article describes a surgical approach integrating biologic tuberoplasty with rotator cuff repair, using an acellular human ...
Evan H. Richman, M.D. +6 more
core +1 more source