Results 51 to 60 of about 10,798 (169)

Statistical Inference in Biological and Diagnostic Systems

, 2020
Biological systems are exceptionally good at sensing their environment with extraordinary precision. Certain single cellular organisms are even capable of detecting chemicals of the order of a single molecule.
Chakrabortty, Tuhin
core  

Use of traditional medicines in the management of HIV/AIDS opportunistic infections in Tanzania: a case in the Bukoba rural district

, 2007
Kisangau DP, Lyaruu HVM, Hosea KM, Joseph CC. Use of traditional medicines in the management of HIV/AIDS opportunistic infections in Tanzania: a case in the Bukoba rural district. Journal of Ethnobiology and Ethnomedicine.
Joseph, Cosam C, Joseph Cosam C, Kisangau Daniel P, Lyaruu, Herbert V. M., Hosea, Ken M., Hosea, Ken M, Lyaruu, Herbert V M, Kisangau, Daniel Patrick, Lyaruu Herbert VM, Joseph, Cosam C., Kisangau, Daniel P, Hosea Ken M   +11 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Establishing diagnostic criteria: the role of clinical pragmatics

, 2012
The study of pragmatic disorders is of interest to speech-language pathologists who have a professional responsibility to assess and treat communication impairments.
Cummings, L
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder

BackgroundAlcohol use disorder (AUD) is associated with increased mortality and morbidity risk. A reason for this could be accelerated biological aging, which is strongly influenced by disease processes such as inflammation. As recent studies of AUD show
Fries, Gabriel R., Zillich, Lea, Fries, Gabriel R, Adorjan, Kristina, Kaerkkaeinen, Olli, Moser, Dirk A., Hansson, Anita C, Sirignano, Lea, Witt, Stephanie H., Streit, Fabian, Frank, Josef, Lohoff, Falk W, Hansson, Anita C., Friske, Marion M, Foo, Jerome C., Foo, Jerome C, Rietschel, Marcella, Cetin, Metin, Kok, Eloise, Kärkkäinen, Olli, Sutherland, Greg T, Sutherland, Greg T., Karhunen, Pekka J., Lohoff, Falk W., Hummel, Elisabeth M., Walss-Bass, Consuelo, Bakalkin, Georgy, Poisel, Eric, Spanagel, Rainer, Moser, Dirk A, Friske, Marion M., Hummel, Elisabeth M, Witt, Stephanie H, Kiefer, Falk, Karhunen, Pekka J, Lenz, Bernd, Hoffmann, Sabine   +36 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa [PDF]

, 2010
Peer ...
Mann, Evleen T., Stubbins, Michael J., Kirsty Kiezebrink, Bujac, Sarah R., Blundell, John E., Campbell, David A., John E. Blundell, Evleen T. Mann, Michael J. Stubbins, David A. Campbell, Sarah R. Bujac, Kiezebrink, Kirsty Margaret   +11 more
core   +1 more source