Results 191 to 200 of about 2,333,106 (317)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Effect of the Extraction Method on the Content of Bioactive Compounds and the Biological Activity of <i>Nigella sativa</i> Extracts. [PDF]

Molecules
Gwiazdowski R, Juś K, Kubiak K, Biegańska-Marecik R, Waśkiewicz A, Gwiazdowska D.   +5 more
europepmc   +1 more source

The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis with Cyclophilin A

, 1995
Vincent Mikol, Christos Papageorgiou, Xaver Borer   +2 more
openalex   +1 more source

Biological Activity Markers Useful in the Diagnosis of Chronic Diarrhea

, 2020
Cristina Voicu, Sorin Rugină
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Novel Needle for Intravitreal Injections Does Not Affect Biological Activity of Anti-VEGF Drugs. [PDF]

Clin Ophthalmol
Lytvynchuk L, Nolte KL, Fuezy I, Zhou W, Deissler H, Deissler HL.   +5 more
europepmc   +1 more source

Enhancing biological SAXS by solvent contrast variation: Effect on structural stability and enzymatic activity

Viviam M. da Silva, Aurélien Thureau, Dominique Madern, Bruno Franzetti, Wanius García, Javier Pérez, Éric Girard, Frank Gabel   +7 more
openalex   +2 more sources

Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

, 2005
Kevin X. Chen, F. George Njoroge, John Pichardo, Andrew Prongay, Nancy Butkiewicz, Nanhua Yao, Vincent Madison, Viyyoor Girijavallabhan   +7 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Purification and Evaluation of the Biological Activity of Recombinant Mouse Prolactin. [PDF]

J Microbiol Biotechnol
Shin YA, Jin H, Lee Y, Shin HB, Son YJ.
europepmc   +1 more source