Results 201 to 210 of about 2,333,106 (317)

Synthesis and biological activity of 1,4-pentadien-3-one derivatives containing triazine scaffolds

, 2020
Xu Tang, Mei Chen, Jun He, Shijun Su, Rongjiao Xia, Tao Guo, Shichun Jiang, Liwei Liu, Wei Xue   +8 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

TAT-Mediated Protein Transduction of Nogo Extracellular Peptide 1-40 and its Biological Activity

, 2008
Qiang Wang, Xingchun Gou, Weilin Jin, Lize Xiong, Lichao Hou, Shaoyang Chen, Hui Zhang, Xiaoling Zhu, Lixian Xu   +8 more
openalex   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Edible Fungi Melanin: Recent Advances in Extraction, Characterization, Biological Activity and Applications. [PDF]

J Fungi (Basel)
Tang J, Shen H, Lv W, Zhang J, Fu J.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Supramolecular self-assemblies of Ru(II) phototherapeutics: biological activity of micro- and nano-particles acting as reservoirs.

J Mater Chem B
Laisney J, Kriger SM, Havrylyuk D, Unrine JM, Heidary DK, Glazer EC.   +5 more
europepmc   +1 more source

The measurement, regulation and biological activity of FAHFAs. [PDF]

Nat Chem Biol
Tan D, Saghatelian A.
europepmc   +1 more source

Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation

, 2003
Ajay Kumar, M. I. HUSAIN, Ashok K. Prasad, Ishwar Singh, Archana Vats, Nawal K. Sharma, Sunil K Sharma, Rajinder K. Gupta, Carl Erik Olsen, Marc Bracke, Richard A. Gross, Virinder S. Parmar   +11 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source