Results 71 to 80 of about 2,333,106 (317)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Functional and applied significance of biological activity of soil

Біологічні студії, 2013
This article provides an overview of scientific information on functional and applied value of soil biological activity and soil processes. Soil is a dynamic alive creation, plant productivity, environmental quality, balance and function of the biosphere
M. Z. Mekich, N. M. Dzhura, O. I. Terek
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Evaluating the in vitro anti-diabetic activity of Bryonia dioica root extracts supported by molecular docking analysis

Digital Chinese Medicine
Objective: To evaluate the in vitro anti-diabetic effects of Bryonia dioica roots extracts, including water-acetone extracts and their ethyl acetate and butanol fractions, and chloroform-methanol extracts. Methods: The total phenolic, flavonoid, flavonol,
Fekhikher Zohra, Benariba Nabila, Radia Brixi Gormat, Hassain Reda, Abdelli Imen, Z. Sekkal Fatima, Kachekouche Youssouf, Taibi Warda, Brikci Sohayb Bekkal, Terki Mohammed, Benramdane Hanane, Adjdir Sara   +11 more
doaj   +1 more source

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses [PDF]

, 2016
Andrew Croaker, Graham J.W. King, John H. Pyne, Shailendra Anoopkumar‐Dukie, Lei Liu   +4 more
openalex   +1 more source

Evaluation of the chemical composition and biological activities of medicinal plants Alkanna tinctoria and Teucrium polium from Turkey

, 2022
Nazan Çömlekçioğlu, Rıdvan Çırak, Akide Karmis, Ashabil Aygan   +3 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Synthesis of diN-Substituted Glycyl-Phenylalanine Derivatives by Using Ugi Four Component Reaction and Their Potential as Acetylcholinesterase Inhibitors

Molecules, 2019
Ugi four component reaction (Ugi-4CR) isocyanide-based multicomponent reactions were used to synthesize diN-substituted glycyl-phenylalanine (diNsGF) derivatives.
Luis Prent-Peñaloza, Alexander F. de la Torre, José L. Velázquez-Libera, Margarita Gutiérrez, Julio Caballero   +4 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Modulation of the biological activities of meningococcal endotoxins by association with outer membrane proteins is not inevitably linked to toxicity [PDF]

, 1997
Emmanuel K. Quakyi, H. Donald Hochstein, Cheng‐Yu Tsai   +2 more
openalex   +1 more source