Results 81 to 90 of about 7,692,235 (287)

Heavy metals, epigenetic aging, and mortality: A cohort study

Ecotoxicology and Environmental Safety
Background: Aging is a multifaceted biological process modulated by interplay of genetic determinants and environmental influences. However, the role of epigenetic aging in the association between environmental exposures and mortality risk in human ...
Hua Wang, Yunyun Liu, Shuxiang Yan, Chenbei Li, Jinxin Tang, Hongkun Hu, Mingyang Wu, Chao Tu   +7 more
doaj   +1 more source

Annual Report - Marine Biological Laboratory, 1895

, 1896
Annual report of the Marine Biological Laboratory in Woods Hole. 1895.
Marine Biological Laboratory (Woods Hole MA)
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1966

, 1967
Annual report of the Marine Biological Laboratory in Woods Hole. 1966.
Marine Biological Laboratory (Woods Hole MA)
core  

DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936

Clinical Epigenetics, 2018
Background The biological mechanisms underlying frailty in older people are poorly understood. There is some evidence to suggest that DNA methylation patterns may be altered in frail individuals.
Catharine R. Gale, Riccardo E. Marioni, Sarah E. Harris, John M. Starr, Ian J. Deary   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1909

, 1910
Annual report of the Marine Biological Laboratory in Woods Hole. 1909.
Marine Biological Laboratory (Woods Hole MA)
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Accelerated biological aging based on DNA methylation clocks is a predictor of stroke occurrence: a systematic review and meta-analysis

Frontiers in Neurology
BackgroundAlthough traditional vascular risk factors, such as hypertension and diabetes, are incorporated into stroke risk prediction models, a significant proportion of stroke events remain unexplained by these models.
Jiacai Feng, Xingyu Huang, Rongqing Wu, Guohui Ding, Ming Liu, Renli Deng   +5 more
doaj   +1 more source

Gestational Diabetes Mellitus and Accelerated Biological Aging in Middle-Aged and Elderly Women

Diabetes Care
OBJECTIVE To evaluate the association between gestational diabetes mellitus (GDM) and accelerated biological aging in middle-aged and elderly women. RESEARCH DESIGN AND METHODS We included parous women with a baseline survey on history
Bin Wang, Ningjian Wang, Xin Yin, Yuhui Huang, Guoqi Yu, Jiaxi Yang, Yap Seng Chong, Yingli Lu, Michelle A. Williams, Frank B. Hu, Cuilin Zhang   +10 more
openaire   +2 more sources