Results 1 to 10 of about 6,994 (169)

Chronological and biological age: Why relevant for psychiatrists?

European Psychiatry, 2021
Introduction Depression is the mental disorder with the largest disease burden impact. That is due to its high prevalence, chronicty, early onset but also due to its impact on various aging-related somatic morbidities and mortality.
B. Penninx
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An integrative study of five biological clocks in somatic and mental health

eLife, 2021
Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and
Rick Jansen, Laura KM Han, Josine E Verhoeven, Karolina A Aberg, Edwin CGJ van den Oord, Yuri Milaneschi, Brenda WJH Penninx   +6 more
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Assessing the Causal Association between Biological Aging Biomarkers and the Development of Cerebral Small Vessel Disease: A Mendelian Randomization Study

Biology, 2023
Biological aging biomarkers, such as leukocyte telomere length (LTL) and epigenetic clocks, have been associated with the risk of cerebral small vessel disease (CSVD) in several observational studies.
Biying Lin, Yuzhu Mu, Zhongxiang Ding
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Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study

Frontiers in Neuroscience, 2023
BackgroundAging is a significant risk factor for many neurodegenerative diseases and neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere length (TL), and epigenetic aging clock acceleration are commonly used ...
Zhiyun Zhang, Ningfang Liu, Xuyang Pan, Chuyi Zhang, Yifan Yang, Xinyun Li, Ying Shao   +6 more
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Sex differences in biological aging with a focus on human studies

eLife, 2021
Aging is a complex biological process characterized by hallmark features accumulating over the life course, shaping the individual's aging trajectory and subsequent disease risks.
Sara Hägg, Juulia Jylhävä
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Spinal Cord Cells from Pre-metamorphic Stages Differentiate into Neurons and Promote Axon Growth and Regeneration after Transplantation into the Injured Spinal Cord of Non-regenerative Xenopus laevis Froglets

Frontiers in Cellular Neuroscience, 2017
Mammals are unable to regenerate its spinal cord after a lesion, meanwhile, anuran amphibians are capable of spinal cord regeneration only as larvae, and during metamorphosis, this capability is lost.
Emilio E. Méndez-Olivos, Rosana Muñoz, Juan Larraín   +2 more
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Historical and Heritage Sustainability for the Revival of Ancient Wine-Making Techniques and Wine Styles

Beverages, 2022
The purpose of this review is to provide a general description of ancient winemaking techniques and wine styles that were most lauded in antiquity, in support of their revival and dissemination today.
Mkrtich Harutyunyan, Manuel Malfeito-Ferreira   +1 more
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Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Nature Communications, 2017
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of ...
Mark Lucanic, W. Todd Plummer, Esteban Chen, Jailynn Harke, Anna C. Foulger, Brian Onken, Anna L. Coleman-Hulbert, Kathleen J. Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B. Crist, Michael P. Presley, Girish Harinath, Christine A. Sedore, Manish Chamoli, Shaunak Kamat, Michelle K. Chen, Suzanne Angeli, Christina Chang, John H. Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A. Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips   +33 more
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Water-soluble CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria

Antioxidants, 2019
Mitochondrial function has been closely associated with normal aging and age-related diseases. Age-associated declines in mitochondrial function, such as changes in oxygen consumption rate, cytochrome c oxidase activity of complex IV, and mitochondrial ...
Mayumi Takahashi, Kazuhide Takahashi
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The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression

Frontiers in Psychiatry, 2020
Losing a spouse is considered one of the most stressful life events a person can experience. Particularly in the immediate weeks and months after the loss, bereavement is associated with a significantly increased risk of morbidity and mortality.
Annina Seiler, Roland von Känel, George M. Slavich   +2 more
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