Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1. [PDF]
, 2015 In vitro and in vivo imaging of protein tyrosine kinase activity requires minimally invasive, molecularly precise optical probes to provide spatiotemporal mechanistic information of dimerization and complex formation with downstream effectors. We present
Acevedo +33 more
core +3 more sources
Predictive Correlation Screening: Application to Two-stage Predictor Design in High Dimension [PDF]
arXiv, 2013 We introduce a new approach to variable selection, called Predictive Correlation Screening, for predictor design. Predictive Correlation Screening (PCS) implements false positive control on the selected variables, is well suited to small sample sizes, and is scalable to high dimensions.
arxiv
Genotoxic evaluation of polymeric nanoparticles
Frontiers in Genetics, 2015 An important strategy for optimizing the therapeutic efficacy of many conventional drugs is the development of polymeric nanoparticles (NPs), as it may expand their activities, reduce their toxicity, increase their bioactivity and improve biodistribution.
Tamara Iglesias Alonso
doaj +1 more source
Ecoenzymes as Indicators of Compost to Suppress Rhizoctonia solani [PDF]
, 2017 Reports of disease suppression by compost are inconsistent likely because there are no established standards for feedstock material, maturity age for application, and application rate.
Fang, Lynn +2 more
core +2 more sources
Tuberculosis and Respiratory Diseases, 2019 Background The purpose of this study was to analyze the relationship between the gene mutation patterns by the GenoType MTBDRplus (MTBDRplus) assay and the phenotypic drug susceptibility test (pDST) results of isoniazid (INH) and prothionamide (Pto).
Joo Hee Lee, M.D. +2 more
doaj
An analytical basis for assaying buried biological contamination Interim report [PDF]
Assay techniques for determining biological contamination of spacecraft ...
Kline, R. C., Randolph, P. L.
core +1 more source
Combustion method for assay of biological materials labeled with carbon-14 or tritium, or double-labeled [PDF]
, 1969 Dry catalytic combustion at high temperatures is used for assaying biological materials labeled carbon-14 and tritium, or double-labeled. A modified oxygen-flask technique is combined with standard vacuum-line techniques and includes convenience of ...
Huebner, L. G., Kisieleski, W. E.
core +1 more source
Sensitivity and specificity of detection methods for erythropoietin doping in cyclists [PDF]
, 2019 Recombinant human erythropoietin (rHuEPO) is used as doping a substance. Anti-doping efforts include urine and blood testing and monitoring the athlete biological passport (ABP).
Burggraaf, Jacobus +10 more
core +1 more source
The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]
, 2014 The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D. +3 more
core +1 more source
The use of quantum dots to amplify antigen detection [PDF]
arXiv, 2017 Proposal to develop an Improved immunological assay employing primary IgG antibodies and secondary IgM antibodies labeled with quantum dots to amplify antigen detection.
arxiv