Results 111 to 120 of about 7,321,210 (347)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Avaliação biológica de soja com baixas atividades de inibidores de tripsina e ausência do inibidor Kunitz

Archivos Latinoamericanos de Nutrición, 2001
Cultivar de soja BR 36 com atividades de inibidores de tripsina convencional e linhagem BRM 95-5262, geneticamente modificadas para conter baixas atividades de inibidores de tripsina, contendo 40 e 20 e 30 e 20% de atividades residuais relativa de ...
Edna Mayumi Yuahasi Miura, Marco Aurélio R. Binotti, Daliane Souza de Camargo, Ivone Yurika Mizubuti, Elza Iouko Ida   +4 more
doaj  

Validation of an Analytical Procedure for Evaluating the Biological Activity of a Medicinal Product Based on Tocilizumab and Determination of Acceptance Criteria for Test Results

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Bioanalytical techniques are characterised by greater variability and lower stability than physicochemical methods because live test systems are inherently labile.
Yu. A. Nikonova, S. G. Abbasova, P. E. Kargopolova, O. M. Strizhakova, I. V. Lyagoskin, A. P. Vasilev, A. S. Pershin   +6 more
doaj   +1 more source

2LabsToGo─Recipe for Building Your Own Chromatography Equipment Including Biological Assay and Effect Detection. [PDF]

Anal Chem, 2022
Sing L, Schwack W, Göttsche R, Morlock GE.   +3 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Comprehensive Evaluation of the Quality of Tripterygium Glycosides Tablets Based on Multi-Component Quantification Combined with an In Vitro Biological Assay. [PDF]

Molecules, 2022
Wang Y, Dai Z, Yan J, Wu X, Ma S.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs. [PDF]

Einstein (Sao Paulo), 2023
Moraes RD, Araujo Júnior E, Castelo Filho A, Peixoto AB, Amed AM.   +4 more
europepmc   +1 more source

The micronucleus assay in radiation accidents [PDF]

, 2009
The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is a standardised and validated technique for biodosimetry. Automated scoring of micronuclei allows large scale applications as in population triage in case of radiation accidents ...
Thierens, Hubert, Vral, Anne
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source