Results 171 to 180 of about 4,740,594 (312)
Annual Report - Marine Biological Laboratory, 1936
, 1937 Annual report of the Marine Biological Laboratory in Woods Hole. 1936.
Marine Biological Laboratory (Woods Hole MA)
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1952
, 1952 Annual report of the Marine Biological Laboratory in Woods Hole. 1952.
Marine Biological Laboratory (Woods Hole MA)
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Discovery of Novel Ligands for TNF-α and TNF Receptor-1 through Structure-Based Virtual Screening and Biological Assay. [PDF]
J Chem Inf Model, 2017 Chen S +7 more
europepmc +1 more source
Annual Report - Marine Biological Laboratory, 1926
, 1927 Annual report of the Marine Biological Laboratory in Woods Hole. 1926.
Marine Biological Laboratory (Woods Hole MA)
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1967
, 1968 Annual report of the Marine Biological Laboratory in Woods Hole. 1967.
Marine Biological Laboratory (Woods Hole MA)
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
An extensive direct assay in biological assay
, 1961 The ordinary method of the biological direct assay has been described by many authors and most investigators being engaged in the biological assay have practiced the method for a long time.
Asano, Choichiro, 浅野, 長一郎
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