Results 151 to 160 of about 4,740,594 (312)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1945
, 1946 Annual report of the Marine Biological Laboratory in Woods Hole. 1945.
Marine Biological Laboratory (Woods Hole MA)
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1957
, 1957 Annual report of the Marine Biological Laboratory in Woods Hole. 1957.
Marine Biological Laboratory (Woods Hole MA)
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study. [PDF]
Molecules, 2018 Wang X, Guo J, Ning Z, Wu X.
europepmc +1 more source
Annual Report - Marine Biological Laboratory, 1983
, 1983 Annual report of the Marine Biological Laboratory in Woods Hole. 1983.
Marine Biological Laboratory (Woods Hole MA)
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A novel medium-throughput biological assay system for HTLV-1 infectivity and drug discovery. [PDF]
Iran J Basic Med Sci, 2017 Abdizadeh MF +4 more
europepmc +1 more source
Annual Report - Marine Biological Laboratory, 1948
, 1948 Annual report of the Marine Biological Laboratory in Woods Hole. 1948.
Marine Biological Laboratory (Woods Hole MA)
core