Results 61 to 70 of about 1,422,405 (264)

Genotoxic evaluation of polymeric nanoparticles

Frontiers in Genetics, 2015
An important strategy for optimizing the therapeutic efficacy of many conventional drugs is the development of polymeric nanoparticles (NPs), as it may expand their activities, reduce their toxicity, increase their bioactivity and improve biodistribution.
Tamara Iglesias Alonso
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Avaliação biológica de soja com baixas atividades de inibidores de tripsina e ausência do inibidor Kunitz

Archivos Latinoamericanos de Nutrición, 2001
Cultivar de soja BR 36 com atividades de inibidores de tripsina convencional e linhagem BRM 95-5262, geneticamente modificadas para conter baixas atividades de inibidores de tripsina, contendo 40 e 20 e 30 e 20% de atividades residuais relativa de ...
Edna Mayumi Yuahasi Miura, Marco Aurélio R. Binotti, Daliane Souza de Camargo, Ivone Yurika Mizubuti, Elza Iouko Ida   +4 more
doaj  

Toxic Activity of Pyrethroids in Lutzomyia longipalpis (Diptera: Psychodidae) from Magdalena River Basin, Colombia

Acta Biológica Colombiana, 2019
The study aimed to determine the toxicity of lambda-cyhalothrin, alpha-cypermethrin, and deltamethrin in L. longipalpis, through concentration-mortality bioassays.
Erika Santamaria, Catalina Marceló-Díaz   +1 more
doaj   +1 more source

Fabrication and In Vitro Biological Assay of Thermo-Mechanically Tuned Chitosan Reinforced Polyurethane Composites. [PDF]

Molecules, 2023
Akram N, Shahzadi I, Zia KM, Saeed M, Ali A, Al-Salahi R, Abuelizz HA, Verpoort F.   +7 more
europepmc   +1 more source

Assay of Thiamine in Biologic Fluids

Clinical Chemistry, 1959
Abstract A method based on the protozoan Ochromonas malhamensis has been developed for assaying thiamine in biologic fluids. It is sensitive, specific and reproducible. Results by this method agree well with other less convenient methods of thiamine assay.
H, BAKER, I, PASHER, O, FRANK, S H, HUTNER, S, AARONSON, H, SOBOTKA   +5 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Validation of an Analytical Procedure for Evaluating the Biological Activity of a Medicinal Product Based on Tocilizumab and Determination of Acceptance Criteria for Test Results

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Bioanalytical techniques are characterised by greater variability and lower stability than physicochemical methods because live test systems are inherently labile.
Yu. A. Nikonova, S. G. Abbasova, P. E. Kargopolova, O. M. Strizhakova, I. V. Lyagoskin, A. P. Vasilev, A. S. Pershin   +6 more
doaj   +1 more source

Biological Assay to Determine Gonadotropin Potency: From In Vivo to In Vitro Sustainable Method. [PDF]

Int J Mol Sci, 2023
Nevelli F, Palmese A, Gleixner R, Peroglio F, D'Acunto CW, Dadone A, D'Hooghe T, Lispi M.   +7 more
europepmc   +1 more source