Results 141 to 150 of about 1,041,160 (240)

E-GuARD: expert-guided augmentation for the robust detection of compounds interfering with biological assays. [PDF]

J Cheminform
Palmacci V, Nahal Y, Welsch M, Engkvist O, Kaski S, Kirchmair J.   +5 more
europepmc   +1 more source

Tetrazole and acylsulfonamide bioisosteric replacements of the carboxylic acid in a dual MCL-1/BCL-x_L inhibitor are tolerated. [PDF]

RSC Adv, 2023
Chen L, Lowe B, Fletcher S.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Integrating Chemo- and Bioinformatics with <i>In Vitro</i> Biological Assays to Discover Potential ACE2 and Mpro Inhibitors against SARS-CoV-2. [PDF]

J Chem Inf Model
Ramos RS, de Souza JSN, Chaves MH, Campos JM, Dantas WM, Pena LJ, Andrade MLDS, Santos CBR.   +7 more
europepmc   +1 more source

Isoamphipathic antibacterial molecules regulating activity and toxicity through positional isomerism. [PDF]

Chem Sci, 2023
Barman S, Mukherjee S, Jolly L, Troiano C, Grottesi A, Basak D, Calligari P, Bhattacharjee B, Bocchinfuso G, Stella L, Haldar J.   +10 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Molecular docking, derivatization, characterization and biological assays of amantadine. [PDF]

Future Med Chem
Yasmeen Z, Khan MA, Ahmad I, Ullah F, Awan B, Akram MT, Khan MR.   +6 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Integration of In Vitro and In Silico Results From Chemical and Biological Assays of Rheum turkestanicum and Calendula officinalis Flower Extracts. [PDF]

Food Sci Nutr
Korpayev S, Zengin G, Ak G, Glamočlija J, Soković M, Aničić N, Gašić U, Stojković D, Agamyradov M, Cetiz MV, Agamyradova G.   +10 more
europepmc   +1 more source