Results 121 to 130 of about 2,986,080 (351)

Biological Clocks as Age Estimation Markers in Animals: From Teeth to DNA, a Review and Meta-analysis (Dataset)

, 2022
Louis‐Stéphane Le Clercq, Antoinette Kotzé, J. Paul Grobler, Desiré L. Dalton   +3 more
openalex   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations

Clinical Epigenetics
DNA methylation (DNAm) has been touted as a potential unified marker of the contributions of both inherited and environmental factors on an individual’s health.
Samuel F. P. Gibbs, Anna P. Pilbrow, Katrina K. Poppe, Nikki J. Earle, Gregory T. Jones, Allamanda F. Faatoese   +5 more
doaj   +1 more source

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention

Nature Aging
Clocks that measure biological age should predict all-cause mortality and give rise to actionable insights to promote healthy aging. Here we applied dimensionality reduction by principal component analysis to clinical data to generate a clinical aging ...
Sheng Fong, Kamil Pabis, Djakim Latumalea, Nomuundari Dugersuren, M. Unfried, Nicholas Tolwinski, Brian K. Kennedy, Jan Gruber   +7 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Cell-type specific circadian transcription factor BMAL1 roles in excitotoxic hippocampal lesions to enhance neurogenesis

iScience
Summary: Circadian clocks, generating daily rhythms in biological processes, maintain homeostasis in physiology, so clock alterations are considered detrimental.
Xuebing Zhang, Suihong Huang, Jin Young Kim   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Setting the pace: host rhythmic behaviour and gene expression patterns in the facultatively symbiotic cnidarian Aiptasia are determined largely by Symbiodinium

Microbiome, 2018
Background All organisms employ biological clocks to anticipate physical changes in the environment; however, the integration of biological clocks in symbiotic systems has received limited attention.
Michal Sorek, Yisrael Schnytzer, Hiba Waldman Ben-Asher, Vered Chalifa Caspi, Chii-Shiarng Chen, David J. Miller, Oren Levy   +6 more
doaj   +1 more source

Macroscopic waves, biological clocks and morphogenesis driven by light in a giant unicellular green alga. [PDF]

Nat Commun, 2023
Afik E, Liu TJB, Meyerowitz EM.
europepmc   +1 more source

Biological clocks and the practice of psychiatry

Dialogues in Clinical Neuroscience, 2007
Endogenous biological clocks enable living species to acquire some independence in relation to time. They improve the efficiency of biological systems, by allowing them to anticipate future constraints on major physyological systems and cell energy ...
P. Schulz
semanticscholar   +1 more source