Results 111 to 120 of about 5,783,416 (253)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Aging clocks based on accumulating stochastic variation

Nature Aging
Aging clocks have provided one of the most important recent breakthroughs in the biology of aging, and may provide indicators for the effectiveness of interventions in the aging process and preventive treatments for age-related diseases.
David H. Meyer, B. Schumacher
semanticscholar   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

jazoller96/mammalian-methyl-clocks: MammalMethylClock R Package: Software for DNA Methylation-Based Epigenetic Clocks in Mammals

<p>First release of MammalMethylClock R package</p> <p>Epigenetic clocks are prediction methods that relate cytosine methylation levels at specific genomic sites to chronological age, in a given species or set of species.
Joseph Zoller
core   +1 more source

Metabolomic-based aging clocks

npj Metabolic Health and Disease
Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks.
A. Ibáñez de Opakua, R. Conde, A. de Diego, M. Bizkarguenaga, N. Embade, S. C. Lu, J. M. Mato, O. Millet   +7 more
doaj   +1 more source

Methylation and algorithms in biological aging: a scoping review

Frontiers in Aging
The role of DNA methylation in the process of biological aging is a particularly active area of research, where methylation changes may be a consequence or a driver in the deviation between biological and chronological age.
Alison Ziesel, Jennifer Reeves, Anastasia Mallidou, Anastasia Mallidou, Lorelei Newton, Lorelei Newton, Ryan E. Rhodes, Ryan E. Rhodes, Jie Zhang, Jie Zhang, Theone Paterson, Theone Paterson, Hosna Jabbari   +12 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations

Clinical Epigenetics
DNA methylation (DNAm) has been touted as a potential unified marker of the contributions of both inherited and environmental factors on an individual’s health.
Samuel F. P. Gibbs, Anna P. Pilbrow, Katrina K. Poppe, Nikki J. Earle, Gregory T. Jones, Allamanda F. Faatoese   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source