Results 111 to 120 of about 72,064 (292)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

In vitro characterisation of murine pre-adipose nucleated cells reveals electrophysiological cycles associated with biological clocks. [PDF]

Electrophoresis, 2022
Martin C, Johnston JD, Henslee EA, van der Veen DR, Labeed FH.   +4 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease

Frontiers in Aging
IntroductionDNA methylation (DNAm) age clocks are powerful tools for measuring biological age, providing insights into aging risks and outcomes beyond chronological age.
David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson   +5 more
doaj   +1 more source

Multi-Modal Regulation of Circadian Physiology by Interactive Features of Biological Clocks. [PDF]

Biology (Basel), 2021
Lee Y, Wisor JP.
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Temporal gene expression patterns in the coral Euphyllia paradivisa reveal the complexity of biological clocks in the cnidarian-algal symbiosis. [PDF]

Sci Adv, 2022
Rinsky M, Weizman E, Ben-Asher HW, Eyal G, Zhu B, Levy O.   +5 more
europepmc   +1 more source

The Physics of Timelessness [PDF]

, 2018
The nature of time is yet to be fully grasped and finally agreed upon among physicists, philosophers, psychologists and scholars from various disciplines.
Ramabrahmam, Varanasi
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Imaging-based organ-specific aging clock predicts human diseases and mortality

npj Digital Medicine
Organ-specific aging clocks hold great potential in reflecting organ health. In vivo imaging is inherently organ-specific and delineates structural and functional characteristics more objectively.
Peng Ren, Wenjing Su, Jia You, Ying Liang, Weikang Gong, Wei Zhang, Zairen Zhou, Fei Dai, Xiaohe Hou, Wei-Shi Liu, Jianfeng Feng, He Wang, Jin-Tai Yu, Wei Cheng   +13 more
doaj   +1 more source