Results 91 to 100 of about 72,064 (292)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The influence of circadian rhythms on carbohydrate metabolism in health and in diabetes mellitus
Сахарный диабетMost processes in the human body and other living organisms are governed by biorhythms. The term biorhythms refers to periodically recurring changes in biological processes.
I. V. Misnikova, D. E. Zoloeva
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Metabolomic-based aging clocks
npj Metabolic Health and DiseaseMolecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks.
A. Ibáñez de Opakua +7 more
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Understanding the retardation of the returned astronaut's clock and GPS clocks using the physical behaviour of moving light clocks [PDF]
, 2007 The prediction of retardation of an astronaut’s clock during a round trip, compared to the clock of the stay-at-home, introduced by Einstein in his 1905 paper has been the most contentious issue for relativity.
McCarthy, Lance
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Methylation and algorithms in biological aging: a scoping review
Frontiers in AgingThe role of DNA methylation in the process of biological aging is a particularly active area of research, where methylation changes may be a consequence or a driver in the deviation between biological and chronological age.
Alison Ziesel +12 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Clinical EpigeneticsDNA methylation (DNAm) has been touted as a potential unified marker of the contributions of both inherited and environmental factors on an individual’s health.
Samuel F. P. Gibbs +5 more
doaj +1 more source