An epigenetic clock for human skeletal muscle [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues.
Sarah Voisin +15 more
doaj +16 more sources
Epigenetic clock as a correlate of anxiety [PDF]
NeuroImage: Clinical, 2020 DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder ...
Klára Marečková +8 more
doaj +5 more sources
A Targeted Epigenetic Clock for the Prediction of Biological Age [PDF]
Cells, 2022 Epigenetic clocks were initially developed to track chronological age, but accumulating evidence indicates that they can also predict biological age.
Noémie Gensous +17 more
doaj +4 more sources
Developmental Tuning of Epigenetic Clock [PDF]
Frontiers in Genetics, 2018 Research in the field of gerontology has traditionally focused on later life stages. There is increasing evidence, however, that both the rate of age-related functional decline and the later-life health status can be programmed during early development ...
Alexander Vaiserman
doaj +4 more sources
A Novel Loop: Mutual Regulation Between Epigenetic Modification and the Circadian Clock [PDF]
Frontiers in Plant Science, 2019 In response to periodic environmental fluctuations generated by the rotation of the earth, nearly all organisms have evolved an intrinsic timekeeper, the circadian clock, which can maintain approximate 24-h rhythmic oscillations in biological processes ...
Shenxiu Du +3 more
doaj +4 more sources
Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients
BMC Psychiatry, 2023 Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li +6 more
doaj +2 more sources
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]
International Journal of Epidemiology, 2015 BACKGROUND: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Riccardo E Marioni +2 more
exaly +2 more sources
The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure [PDF]
Neurobiology of Stress, 2021 Background: Studies reporting accelerated ageing in children with affective disorders or maltreatment exposure have relied on algorithms for estimating epigenetic age derived from adult samples.
Felix Dammering +11 more
doaj +2 more sources
An epigenetic clock for Xenopus tropicalis [PDF]
npj AgingDNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in developmental ...
Bennett, Ronan
core +4 more sources
Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
Translational Neurodegeneration, 2021 The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age.
Miao Xu +4 more
doaj +2 more sources