Results 31 to 40 of about 35,251 (213)
Inverse relationship between genetic diversity and epigenetic complexity [PDF]
, 2008 Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core +3 more sources
Nature Communications, 2022 The temporal development of tissues and organs may be defined by the genome-wide epigenetic and transcriptional state functioning as the clock. Here the authors found that Fbl, a ribosomal RNA methyltransferase, potentially behaves as a clock during ...
Quan Wu +7 more
doaj +1 more source
An evolutionary epigenetic clock in plants
Science, 2023 Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (~10 5 to 10 8 years). However, classical DNA-based clocks tick too slowly to inform us about the recent past.
Yao, N. +12 more
openaire +7 more sources
Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus
Frontiers in Genetics, 2022 Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj +1 more source
DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]
, 2018 DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola +3 more
core +1 more source
Circadian clock: linking epigenetics to aging [PDF]
Current Opinion in Genetics & Development, 2014 Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features.
Orozco-Solis, Ricardo +1 more
openaire +4 more sources
Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
GeroScience, 2023 Abstract Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than ...
Dec, Eric +24 more
openaire +6 more sources
A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics [PDF]
, 2019 Cellular, organ, and whole animal physiology show temporal variation predominantly featuring 24-h (circadian) periodicity. Time-course mRNA gene expression profiling in mouse liver showed two subsets of genes oscillating at the second (12-h) and third (8-
Biagini, Tommaso +11 more
core +1 more source
Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort. [PDF]
Alzheimers Dement (Amst)Savin MJ +13 more
europepmc +3 more sources
Epigenetic clock and methylation studies in elephants. [PDF]
Aging Cell, 2021 ABSTRACTAge-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age (“epigenetic clocks”) in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants.
Prado NA +11 more
europepmc +4 more sources