Results 31 to 40 of about 317,209 (276)

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Genome Biology, 2019
Background Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process.
Daniel E. Martin-Herranz, Erfan Aref-Eshghi, Marc Jan Bonder, Thomas M. Stubbs, Sanaa Choufani, Rosanna Weksberg, Oliver Stegle, Bekim Sadikovic, Wolf Reik, Janet M. Thornton   +9 more
doaj   +1 more source

Repressor dimerization in the zebrafish somitogenesis clock [PDF]

, 2007
The oscillations of the somitogenesis clock are linked to the fundamental process of vertebrate embryo segmentation, yet little is known about their generation.
Olivier Cinquin, Cinquin, O
core   +2 more sources

Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination

Frontiers in Genetics, 2022
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome.
Alina P. S. Pang, Albert T. Higgins-Chen, Albert T. Higgins-Chen, Florence Comite, Florence Comite, Ioana Raica, Christopher Arboleda, Hannah Went, Tavis Mendez, Michael Schotsaert, Michael Schotsaert, Varun Dwaraka, Ryan Smith, Morgan E. Levine, Lishomwa C. Ndhlovu, Michael J. Corley   +15 more
doaj   +1 more source

Low-cost on-chip clock jitter measurement scheme [PDF]

, 2014
In this paper, we present a low-cost, on-chip clock jitter digital measurement scheme for high performance microprocessors. It enables in situ jitter measurement during the test or debug phase.
Giaffreda, Daniele, Rahman A., Omana, Martin, Rossi D., Tam, S., Omana M., Omana, M., Metra C., Metra, C., Mak, TM, Rahman, A., Rossi, Daniele, S. Tam, Giaffreda, D., Metra, Cecilia, Raman, Asifur, A. Rahman, Mak, T.M., Mak T. M., D. Giaffreda, TM Mak, Giaffreda D., Tam, Simon, Tam S., OMANA, MARTIN EUGENIO, Rossi, D.   +25 more
core   +1 more source

Circadian clock: linking epigenetics to aging [PDF]

Current Opinion in Genetics & Development, 2014
Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features.
Orozco-Solis, Ricardo, Sassone-Corsi, Paolo   +1 more
openaire   +4 more sources

Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

Translational Neurodegeneration, 2021
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age.
Miao Xu, JiaYi Zhu, Xian-Dong Liu, Ming-Ying Luo, Nan-Jie Xu   +4 more
doaj   +1 more source

An epigenetic clock controls aging [PDF]

Biogerontology, 2015
We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have seen that signaling chemistry can make dramatic differences in life span, and that single molecules can significantly affect ...
openaire   +4 more sources

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Ducasse, Miryam, Brown, Mark A., Ducasse Miryam, Brown Mark A   +3 more
core   +1 more source

Cardiovascular health and four epigenetic clocks

Clinical Epigenetics, 2022
Abstract Background Cardiovascular health (CVH) was defined by the American Heart Association as an integrative idealness of seven clinical or lifestyle factors. Based on populations of European ancestry, recent studies have shown that ideal CVH is associated with a slower aging rate. The aging rate is measured by levels
Yun-Hsiang Lo, Wan-Yu Lin
openaire   +2 more sources

Estimating Polar Bear (Ursus maritimus) Age Based on an Epigenetic DNA Methylation Clock

Ecology and Evolution
Knowledge of animal age is essential to wildlife managers for obtaining meaningful and accurate insights into demographic parameters. A common approach to aging wildlife, including bears (Ursus spp.), has been extracting a tooth during physical capture ...
Susannah P. Woodruff, Milda Milčiūtė, Juozas Gordevičius, Robert Brooke, Todd C. Atwood   +4 more
doaj   +1 more source