Results 11 to 20 of about 35,251 (213)
Epigenetic Clock: DNA Methylation in Aging [PDF]
Stem Cells International, 2020 Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regulators involved in this process ...
Shuang Jiang, Yuchen Guo
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Epigenetic clock and methylation studies in cats. [PDF]
Geroscience, 2021 Abstract Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in ...
Raj K +8 more
europepmc +7 more sources
An epigenetic clock for human skeletal muscle [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues.
Sarah Voisin +15 more
doaj +7 more sources
Characteristics of Epigenetic Clocks Across Blood and Brain Tissue in Older Women and Men [PDF]
Frontiers in Neuroscience, 2021 Epigenetic clocks are among the most promising biomarkers of aging. It is particularly important to establish biomarkers of brain aging to better understand neurodegenerative diseases.
Francine Grodstein +8 more
doaj +2 more sources
An epigenetic clock controls aging [PDF]
Biogerontology, 2015 We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have seen that signaling chemistry can make dramatic differences in life span, and that single molecules can significantly affect ...
Josh Mitteldorf
openalex +5 more sources
Developmental Tuning of Epigenetic Clock [PDF]
Frontiers in Genetics, 2018 Research in the field of gerontology has traditionally focused on later life stages. There is increasing evidence, however, that both the rate of age-related functional decline and the later-life health status can be programmed during early development ...
Alexander Vaiserman
doaj +3 more sources
Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes [PDF]
Advanced ScienceEpigenetic clocks in blood have shown promise as tools to quantify biological age, displaying robust associations with morbidity and all‐cause mortality.
Xiaolong Guo +17 more
doaj +2 more sources
Epigenetics, 2018 Horvath’s epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we investigated the conformation, energy characteristics and presence of tentative splice sites of the ...
Andigoni Malousi +5 more
doaj +2 more sources
An epigenetic clock for Xenopus tropicalis. [PDF]
NPJ AgingAbstract DNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in developmental biology and genomics.
Bennett R +4 more
europepmc +3 more sources
Epigenetic events influencing the biological clock: Panacea for neurodegeneration
HeliyonThe human biological clock is the 24-h internal molecular network of circadian genes in synchronization with other cells in response to external stimuli.
Indrani Paramasivan Latha Laxmi +1 more
doaj +2 more sources