Results 11 to 20 of about 2,105 (236)
Epigenetics, 2020 Vitamin D could be beneficial for healthy ageing in humans. We previously found that vitamin D supplementation may slow down epigenetic ageing in young African American adults.
Li Chen +7 more
doaj +2 more sources
Back to the future: Epigenetic clock plasticity towards healthy aging
Mechanisms of Ageing and Development, 2018 : Aging is the most important risk factor for major human lifestyle diseases, including cancer, neurological and cardiometabolic disorders. Due to the complex interplay between genetics, lifestyle and environmental factors, some individuals seem to age ...
Ken Declerck, Wim Vanden Berghe
exaly +2 more sources
Perfect timing: Epigenetic regulation of the circadian clock [PDF]
FEBS Letters, 2011 In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post-genetic molecular mechanism is one of ...
Ripperger, Juergen A. +6 more
core +5 more sources
Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and Rejuvenation
Journal of Personalized Medicine, 2021 This review summarizes the current understanding of the interaction between circadian rhythms of gene expression and epigenetic clocks characterized by the specific profile of DNA methylation in CpG-islands which mirror the senescence of all somatic ...
Ekaterina M Samoilova +2 more
exaly +2 more sources
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
Aging Cell, 2021 Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length.
Paweł Kordowitzki +2 more
exaly +2 more sources
On the epigenetic ageing clock in humans
, 2019 Epigenetic clocks are mathematical models that predict the biological age of an organism using DNA methylation data, and which have emerged in the last few years as the most accurate biomarkers of the ageing process.
core +2 more sources
Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
Cell, 2012 The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be ...
Thomas A Rando, Howard Y Chang
exaly +2 more sources
Epigenetic Clocks and Programmatic Aging
Ageing Research Reviews, 2023 The last decade has seen remarkable progress in the characterization of methylation clocks that track biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms.
David Gems +2 more
openaire +3 more sources
An evolutionary epigenetic clock in plants
Science, 2023 Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (~10 5 to 10 8 years). However, classical DNA-based clocks tick too slowly to inform us about the recent past.
Yao, N. +12 more
openaire +8 more sources
Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids
Communications Biology, 2021 Larison et al. report epigenetic aging models in plains zebras (Equus quagga) using the epigenetic clock and epigenetic pacemaker approaches. Their epigenetic clock allows age to be accurately estimated in endangered sister species, and the pacemaker ...
Brenda Larison +13 more
doaj +1 more source