Results 41 to 50 of about 2,105 (236)

Demographic and clinical characteristics as well as epigenetic clock acceleration.

, 2022
Demographic and clinical characteristics as well as epigenetic clock acceleration.
Ryo Kimura (3237978), Toshiya Murai (823193), Satoshi Okazaki (3514487), Akitoyo Hishimoto (683502), Yasuko Funabiki (7527356), Ikuo Otsuka (4734996)   +5 more
core   +1 more source

Inverse relationship between genetic diversity and epigenetic complexity

, 2008
Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core   +1 more source

Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle

, 2015
The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Haslam, Iain S., Iain S Haslam, Jonathan A Hardman, Hardman, Jonathan A, Bessam Farjo (714627), Farjo, Bessam, Nilofer Farjo (714626), Nilofer Farjo, Jonathan A. Hardman (714625), Ralf Paus, Farjo, Nilofer, Bessam Farjo, Iain S. Haslam (452871), Haslam, Iain S, Hardman, Jonathan A., Paus, Ralf, Ralf Paus (261703)   +16 more
core   +1 more source

Epigenetic clock and methylation studies in elephants

Aging Cell, 2020
ABSTRACT Age-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age (“epigenetic clocks”) in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants.
Natalia A. Prado, Janine L. Brown, Joseph A. Zoller, Amin Haghani, Mingjia Yao, Lora R. Bagryanova, Michael G. Campana, Jesús E. Maldonado, Ken Raj, Dennis Schmitt, Todd R. Robeck, Steve Horvath   +11 more
openaire   +3 more sources

Epigenetic Clock Coefficients and Age predictions

, 2022
Epigenetic Clock Coefficients is an Excel file that contains two sheets. One sheet contains the coefficients for predicting the age of 26 species of bats from DNA methylation values obtained from DNA extracted from wing punches and then profiled using an
Danielle M. Adams (6506693), Gerald Wilkinson (747363)   +1 more
core   +1 more source

Epigenetic clocks are not accelerated in COVID-19 patients [PDF]

International Journal of Molecular Sciences, 2020
Abstract Age is a major risk factor for severe outcome of coronavirus disease 2019 (COVID-19), but it remains unclear if this is rather due to increased chronological age or biological age. During lifetime, specific DNA methylation changes are acquired in our genome that act as “epigenetic clocks” allowing to estimate donor age and to ...
Julia Franzen, Selina Nüchtern, Vithurithra Tharmapalan, Margherita Vieri, Miloš Nikolić, Yang Han, Paul Balfanz, Nikolaus Marx, Michael Dreher, Tim H. Brümmendorf, Edgar Dahl, Fabian Beier, Wolfgang Wagner   +12 more
openaire   +4 more sources

Estimating Polar Bear (Ursus maritimus) Age Based on an Epigenetic DNA Methylation Clock

Ecology and Evolution
Knowledge of animal age is essential to wildlife managers for obtaining meaningful and accurate insights into demographic parameters. A common approach to aging wildlife, including bears (Ursus spp.), has been extracting a tooth during physical capture ...
Susannah P. Woodruff, Milda Milčiūtė, Juozas Gordevičius, Robert Brooke, Todd C. Atwood   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial)

Scientific Reports
Plasmapheresis is a medical procedure that separates plasma from blood cells, potentially removing pro-aging factors from circulation. Some studies suggest it may have rejuvenating effects by altering biomarkers of aging, but evidence on its impact on ...
Pavel Borsky, Drahomira Holmannova, Helena Parova, Steve Horvath, Petr Sramek, Robert T. Brooke, Milda Milciute, Juozas Gordevicius, Zdenek Fiala, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Ivana Baranova, Natalia Matyasovska, Lenka Borska   +14 more
doaj   +1 more source

Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity

GeroScience, 2023
Abstract Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than ...
Dec, Eric, Clement, James, Cheng, Kaiyang, Church, George M., Fossel, Michael B., Rehkopf, David H., Rosero-Bixby, Luis, Kobor, Michael S., Lin, David TS., Lu, Ake T., Fei, Zhe, Guo, Wei, Chew, Yap Ching, Yang, Xiaojing, Putra, Sulistyo E. Dwi, Reiner, Alex P., Correa, Adolfo, Vilalta, Adrian, Pirazzini, Chiara, Passarino, Giuseppe, Monti, Daniela, Arosio, Beatrice, Garagnani, Paolo, Franceschi, Claudio, Horvath, Steve   +24 more
openaire   +6 more sources