Results 41 to 50 of about 35,251 (213)

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Genome Biology, 2019
Background Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process.
Daniel E. Martin-Herranz, Erfan Aref-Eshghi, Marc Jan Bonder, Thomas M. Stubbs, Sanaa Choufani, Rosanna Weksberg, Oliver Stegle, Bekim Sadikovic, Wolf Reik, Janet M. Thornton   +9 more
doaj   +1 more source

Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination

Frontiers in Genetics, 2022
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome.
Alina P. S. Pang, Albert T. Higgins-Chen, Albert T. Higgins-Chen, Florence Comite, Florence Comite, Ioana Raica, Christopher Arboleda, Hannah Went, Tavis Mendez, Michael Schotsaert, Michael Schotsaert, Varun Dwaraka, Ryan Smith, Morgan E. Levine, Lishomwa C. Ndhlovu, Michael J. Corley   +15 more
doaj   +1 more source

Corticotropin-releasing hormone as the homeostatic rheostat of feto-maternal symbiosis and developmental programming In utero and neonatal life [PDF]

, 2017
A balanced interaction between the homeostatic mechanisms of mother and the devel- oping organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal ...
Alcantara-Alonso, Alexander, Arborelius, Bale, Baram, Barker, Bellisario, Benjamin Neelon, Bosch, Bouret, Bowman, Briana, Brummelte, Brunson, Brunton, Brunton, Brunton, Brunton, Capron, Chen, Chen, Choy, Cirulli, Cirulli, Class, Clifton, Cottrell, Dallman, Davis, de Weerth, Demendi, Desai, Dimasuay, Dunkel, D’Amato, Eghbal-Ahmadi, Ehlers, Ellman, Entringer, Fasting, Faturi, Fenoglio, Gao, Gillman, Glynn, Gomez-Roig, Grammatopoulos, Gunnar, Harville, Hollrigel, Husum, Ibanez, Kammerer, Kensara, Korosi, Labonte, Ladyman, Larsen, Lee, Lockwood, Machado, MacKay, Maffeis, Magiakou, Maniam, Marciniak, McLean, Mingrone, Owens, Pasquali, Paternain, Pedersen, Pelleymounter, Peng, Perrone, Pervanidou, Petraglia, Pihoker, Plotsky, Purcell, Robinson, Romens, Sanchez, Sandman, Sandman, Schmidt, Schulte, Seckl, Seckl, Sferruzzi-Perri, Shapiro, Singh-Taylor, Smith, Soma-Pillay, Stout, Suderman, Sun, Symonds, Tamashiro, Turecki, van Bodegom, Vazquez, Vickers, Wadhwa, Wakahashi, Walker, Wang, Weaver, Weaver, Weinstock, Whitaker, Whitehead, Wolfe, Yam, Zambrano   +114 more
core   +3 more sources

Menopause accelerates biological aging [PDF]

, 2016
Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently, we developed a highly accurate epigenetic biomarker of age (known as the “epigenetic clock ...
Absher, D, Assimes, TL, Bandinelli, S, Chen, BH, Ferrucci, L, Hernandez, DG, Horvath, S, Kuh, D, Kusters, CDJ, Levine, ME, Lu, AT, Manson, JE, Quach, A, Ritz, BR, Salfati, E, Singleton, AB, Teschendorff, AE, Widschwendter, M, Wong, A   +18 more
core   +1 more source

A Novel Loop: Mutual Regulation Between Epigenetic Modification and the Circadian Clock

Frontiers in Plant Science, 2019
In response to periodic environmental fluctuations generated by the rotation of the earth, nearly all organisms have evolved an intrinsic timekeeper, the circadian clock, which can maintain approximate 24-h rhythmic oscillations in biological processes ...
Shenxiu Du, Liang Chen, Liangfa Ge, Wei Huang   +3 more
doaj   +1 more source

DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. [PDF]

, 2020
Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains ...
Coppola, Giovanni, Horvath, Steve, Jones, D Leanne, Lewis, Sophia K, Martin, Martin G, Nachun, Daniel   +5 more
core  

Circadian clocks and breast cancer [PDF]

, 2016
Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V, Meng, Q-J, Streuli, CH, Williams, JL   +3 more
core   +2 more sources

Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization. [PDF]

, 2016
RRx-001, an experimental systemically non-toxic epi-immunotherapeutic agent, which potentiates the resensitization of resistant cancer cells to formerly effective therapies, is under active investigation in several clinical trials that are based on ...
Brzezniak, Christina, Cabrales, Pedro, Caroen, Scott Z, Carter, Corey A, Degesys, Aiste, Jenkins, John, Oronsky, Bryan T, Reid, Tony, Scicinski, Jan J   +8 more
core   +3 more sources

Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

Translational Neurodegeneration, 2021
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age.
Miao Xu, JiaYi Zhu, Xian-Dong Liu, Ming-Ying Luo, Nan-Jie Xu   +4 more
doaj   +1 more source

m6a RNA methylation: the implications for health and disease [PDF]

, 2014
The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core   +1 more source