Results 41 to 50 of about 317,209 (276)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial)

Scientific Reports
Plasmapheresis is a medical procedure that separates plasma from blood cells, potentially removing pro-aging factors from circulation. Some studies suggest it may have rejuvenating effects by altering biomarkers of aging, but evidence on its impact on ...
Pavel Borsky, Drahomira Holmannova, Helena Parova, Steve Horvath, Petr Sramek, Robert T. Brooke, Milda Milciute, Juozas Gordevicius, Zdenek Fiala, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Ivana Baranova, Natalia Matyasovska, Lenka Borska   +14 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples

Communications Biology
This study aims to evaluate differences between Infinium MethylationEPIC (EPICv1) and Infinium MethylationEPICv2 (EPICv2) arrays in estimating DNAm age with eleven DNAm clocks using buffy coat, peripheral blood mononuclear cell (PBMC), and saliva from 16
Jian Hua Tay, Yi Ern Chew, Weilan Wang, Zhi Meng Lim, Lihuan Guan, Rajkumar Dorajoo, Brian K. Kennedy, Robert Brooke, Juozas Gordevicius, Steve Horvath, Elena Sandalova, Andrea B. Maier   +11 more
doaj   +1 more source

Recalibrating the epigenetic clock after exposure to trauma: The role of risk and protective psychosocial factors

, 2022
Background: Epigenetic aging is associated with a plethora of negative health outcomes and increased mortality. Yet, the dynamicity of epigenetic age after exposure to trauma and the factors that influence epigenetic age are not fully understood.
Stringfellow, Rachel, Bruenig, Dagmar, Sathyanarayanan, Anita, Mehta, Divya, Mullens, Amy B., Shakespeare-Finch, Jane, Pierce, John, Miller, Olivia   +7 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-moderate probable Alzheimer's disease

Frontiers in Neuroscience
IntroductionAging is the primary risk factor for sporadic Alzheimer's disease. Chronic low-grade inflammation associated with aging drives cognitive impairment through multiple mechanisms involving oxidative stress, insulin resistance, and dysregulation ...
Christopher L. Reading, Jiayan Yan, Marcia A. Testa, Donald C. Simonson, Hira Javaid, Lisa Schmunk, Daniel E. Martin-Herranz, Robert Brooke, Juozas Gordevicius, Jeffrey Zhang, Harvey Yuan, Clarence Ahlem, Lixia Wang, Penelope Markham, Nily Osman, Stephen O'Quinn, Joseph Palumbo   +16 more
doaj   +1 more source

Multi-tissue DNA methylation age predictor in mouse

Genome Biology, 2017
Background DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an underlying ageing process.
Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, BI Ageing Clock Team, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik   +7 more
doaj   +1 more source

Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity

GeroScience, 2023
Abstract Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than ...
Dec, Eric, Clement, James, Cheng, Kaiyang, Church, George M., Fossel, Michael B., Rehkopf, David H., Rosero-Bixby, Luis, Kobor, Michael S., Lin, David TS., Lu, Ake T., Fei, Zhe, Guo, Wei, Chew, Yap Ching, Yang, Xiaojing, Putra, Sulistyo E. Dwi, Reiner, Alex P., Correa, Adolfo, Vilalta, Adrian, Pirazzini, Chiara, Passarino, Giuseppe, Monti, Daniela, Arosio, Beatrice, Garagnani, Paolo, Franceschi, Claudio, Horvath, Steve   +24 more
openaire   +6 more sources