Results 1 to 10 of about 5,479,707 (298)

Epigenetic age and neurodevelopmental outcomes in children born preterm [PDF]

Genetics in Medicine Open
Purpose: The objective of this study was to identify predictors of epigenetic age and its association with neurodevelopmental outcomes in children born preterm.
Rhandi Christensen, Chaini Konwar, Beryl C. Zhuang, Michael S. Kobor, Vann Chau, Anne Synnes, Ting Guo, Julia MacIsaac, Ruth E. Grunau, Steven P. Miller   +9 more
doaj   +2 more sources

EnsembleAge clock: a reliable and robust epigenetic age clock service reveals epigenetic age acceleration in opioid-overdosed brains [PDF]

BMC Genomics
Age is a major risk factor for various diseases, such as cancer, cardiovascular conditions, and neurodegenerative diseases. However, chronological age, the simple number of years one has lived, does not capture individual health differences, prompting ...
Akshay Anand, Yash Agarwal, Tanisha Gupta, Jason Lin, Mirna Ghemrawi, Glenn S. Gerhard, Hayan Lee   +6 more
doaj   +2 more sources

Epigenetic Age Feedback as a Catalyst for Sustained Lifestyle Change: One-Year Results from the EU iHelp Study [PDF]

Epigenomes
Background: Sustaining long-term lifestyle change remains a major challenge in preventive health. Epigenetic clocks offer a dynamic, modifiable measure of biological ageing that may enhance motivation when returned to individuals.
Nien-yu Yang, Yicong Huang, Chaewon Park, Te-Min Ke, Graham Tilston, George Manias, Dimosthenis Kyriazis, Jon Young, Susan Hart, Graham Fulford, Artitaya Lophatananon, Kenneth R. Muir   +11 more
doaj   +2 more sources

Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort

Biology, 2022
We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardiometabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, n = 306; aged 45–69 years ...
Olga Chervova, Elizabeth Chernysheva , Kseniia Panteleeva , Tyas Arum Widayati , Natalie Hrbkova, Jadesada Schneider , Vladimir Maximov , Andrew Ryabikov , Taavi Tillmann , Hynek Pikhart, Martin Bobak , Vitaly Voloshin , Sofia Malyutina , Stephan Beck    +13 more
doaj   +1 more source

Brain region-specific genome-wide deoxyribonucleic acid methylation analysis in patients with Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2023
ObjectiveAlzheimer’s disease (AD) is a neurodegenerative disease characterized by neuropathology and cognitive decline and associated with age. The comprehensive deoxyribonucleic acid methylation (DNAm)-transcriptome profile association analysis ...
Gang Ren, Shan Song, Shan Song, Sheng-Xiao Zhang, Sheng-Xiao Zhang, Yan Liu, Yan Liu, Yan Lv, Yan-Hong Wang, Rong Zhao, Rong Zhao, Xin-Yi Li   +11 more
doaj   +1 more source

DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort

Clinical Epigenetics, 2023
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment.
Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert, Andres Cardenas   +6 more
doaj   +1 more source

The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging

Biomedicines, 2022
One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose ...
Ana I. Hernandez Cordero, Chen Xi Yang, Xuan Li, Julia Yang, Tawimas Shaipanich, Julie L. MacIsaac, David T. S. Lin, Michael S. Kobor, Steve Horvath, Shu Fan Paul Man, Don D. Sin, Janice M. Leung   +11 more
doaj   +1 more source

The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease

Frontiers in Aging Neuroscience, 2022
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease with variable clinical manifestations. Recent studies highlighted the contribution of epigenetic alterations to HD progress and onset. The potential crosstalk between different
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Taheri, Kaveh Ebrahimzadeh, Rezvan Noroozi   +7 more
doaj   +1 more source

Influence of obesity on biological age in patients with arterial hypertension

Arterial Hypertension, 2023
BACKGROUND: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension.
Olena Kolesnikova, Olga Zaprovalna, Tetiana Bondar, Anna Potapenko   +3 more
doaj   +1 more source

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort

Epigenetics, 2022
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood.
Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A. Collender, Jamaji C. Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas   +9 more
doaj   +1 more source