Results 31 to 40 of about 5,479,707 (298)

Epigenetic epidemiology and alterations in type 2 diabetes and obesity

, 2022
ype 2 diabetes (T2D) and obesity are multifactorial and polygenic metabolic diseases. Combinations of genetic and non-genetic risk factors such as risk SNPs, age, unhealthy diets, and physical inactivity increase the risk for these diseases.
Ling, Charlotte,, Ruhrmann, Sabrina,, Rönn, Tina,, Bacos, Karl,, Lund University., Säll, Johanna,   +5 more
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Epigenetic mechanisms in Tendon Ageing [PDF]

British Medical Bulletin, 2020
AbstractIntroductionTendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes.
Riasat, Kiran, Bardell, David, Goljanek-Whysall, Kasia, Clegg, Peter, Peffers, Mandy   +4 more
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Evaluation of Epigenetic Age Based on DNA Methylation Analysis of Several CpG Sites in Ukrainian Population

Frontiers in Genetics, 2022
Epigenetic clocks are the models, which use CpG methylation levels for the age prediction of an organism. Although there were several epigenetic clocks developed there is a demand for development and evaluation of the relatively accurate and sensitive ...
N. Kuzub, V. Smialkovska, V. Momot, V. Moseiko, O. Lushchak, A. Koliada, A. Koliada   +6 more
doaj   +1 more source

Epigenetic-based therapies for Friedreich ataxia [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Friedreich ataxia (FRDA) is a lethal autosomal recessive neurodegenerative disorder caused primarily by a homozygous GAA repeat expansion mutation within the first intron
Madhavi Sandi, Al-Mahdawi, S, Sahar eAl-Mahdawi, Chiranjeevi eSandi, Madhavi eSandi, Sara eAnjomani-Virmouni, Sandi, C, Virmouni, SA, Sandi, M, Pook, MA, Mark Adrian Pook, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sara Anjomani Virmouni, Mark A. Pook   +14 more
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The Epigenetics of Aging in Invertebrates [PDF]

International Journal of Molecular Sciences, 2019
Aging is an unstoppable process coupled to the loss of physiological function and increased susceptibility to diseases. Epigenetic alteration is one of the hallmarks of aging, which involves changes in DNA methylation patterns, post-translational modification of histones, chromatin remodeling and non-coding RNA interference.
Guixiang Yu, Qi Wu, Yue Gao, Meiling Chen, Mingyao Yang   +4 more
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Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Epigenetics, 2023
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta   +11 more
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Age-associated hyper-methylated regions in the human brain overlap with bivalent chromatin domains [PDF]

, 2012
Recent associations between age-related differentially methylated sites and bivalently marked chromatin domains have implicated a role for these genomic regions in aging and age-related diseases. However, the overlap between such epigenetic modifications
Giulio Disanto, Giovannoni Gavin, Gavin Giovannoni, Ramagopalan Sreeram V., Sandve, GK, Watson Corey T., Ramagopalan, SV, Watson, CT, Sandve Geir Kjetil, Ramagopalan, Sreeram, Sreeram V Ramagopalan, Disanto Giulio, Breden Felix, Corey T Watson, Felix Breden, Breden, F, Giovannoni, G, Geir Kjetil Sandve, Disanto, G   +18 more
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Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Epigenetics, 2023
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health.
Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix   +7 more
doaj   +1 more source

Profiling age-related epigenetic markers of stomach adenocarcinoma in young and old subjects [PDF]

, 2015
The purpose of our study is to identify epigenetic markers that are differently expressed in the stomach adenocarcinoma (STAD) condition. Based on data from The Cancer Genome Atlas (TCGA), we were able to detect an age-related difference in methylation ...
Kim, Byoung-Chul, Byung Pal Yu, Park, Daeui, Bhak, Jong Hwa, Jeong, Hyoung Oh, Eunok Im, Sunghoon Lee, Kim, Nam Deuk, Hae Young Chung, Chung, Hae Young, Jong Bhak, Lee, Eun Kyeong, Lee, Sunghoon, Kim, Chul-Hong, Yu, Byung Pal, Eun Kyeong Lee, Im, Eunok, Nam Deuk Kim, Chul-Hong Kim, Hyoung Oh Jeong, Daeui Park, Dae Hyun Kim, Byoung-Chul Kim, Kim, Dae Hyun   +23 more
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Epigenetics of Aging and Aging-Associated Diseases [PDF]

International Journal of Molecular Sciences, 2021
Aging represents the multifactorial decline in physiological function of every living organism. Over the past decades, several hallmarks of aging have been defined, including epigenetic deregulation. Indeed, multiple epigenetic events were found altered across different species during aging.
Saul, Dominik, Kosinsky, Robyn Laura, Saul, Dominik; Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA, Saul.Dominik@mayo.edu Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, 37075 Goettingen, Germany, Saul.Dominik@mayo.edu, Kosinsky, Robyn Laura; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA, Kosinsky.RobynLaura@mayo.edu   +3 more
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