Results 31 to 40 of about 365,239 (262)

Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Epigenetics, 2023
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta   +11 more
doaj   +1 more source

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Epigenetics, 2023
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health.
Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix   +7 more
doaj   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Epigenetics, 2022
Maternal pregnancy fatty acid status is associated with child health. Epigenetic gestational age acceleration, referring to a discrepancy between chronological and epigenetic gestational age, may underlie these associations.
Giulietta S. Monasso, Trudy Voortman, Janine F. Felix   +2 more
doaj   +1 more source

Open access-enabled evaluation of epigenetic age acceleration in colorectal cancer and development of a classifier with diagnostic potential

Frontiers in Genetics, 2023
Aberrant DNA methylation (DNAm) is known to be associated with the aetiology of cancer, including colorectal cancer (CRC). In the past, the availability of open access data has been the main driver of innovative method development and research training ...
Tyas Arum Widayati, Jadesada Schneider, Jadesada Schneider, Kseniia Panteleeva, Elizabeth Chernysheva, Natalie Hrbkova, Stephan Beck, Vitaly Voloshin, Olga Chervova   +8 more
doaj   +1 more source

From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]

, 2018
Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R., C., Squarcina, Carli, De, F., Brambilla, F., Sirgiovanni, Fumagalli, M., I., Giorda, L., Pozzoli, Montirosso, Rosario, Mosca, F., P., Dessimone, Provenzi, L., R., Cinnante, U., Triulzi   +13 more
core   +1 more source

Maternal prenatal depression and epigenetic age deceleration: testing potentially confounding effects of prenatal stress and SSRI use

Epigenetics, 2021
Previous studies suggest epigenetic alterations may contribute to the association between maternal prenatal depression and adverse offspring outcomes. Developmental researchers have recently begun to examine these associations in relation to epigenetic ...
Brooke G. McKenna, Cassandra L. Hendrix, Patricia A. Brennan, Alicia K. Smith, Zachary N. Stowe, D. Jeffrey Newport, Anna K. Knight   +6 more
doaj   +1 more source

Menopause accelerates biological aging [PDF]

, 2016
Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently, we developed a highly accurate epigenetic biomarker of age (known as the “epigenetic clock ...
Absher, D, Assimes, TL, Bandinelli, S, Chen, BH, Ferrucci, L, Hernandez, DG, Horvath, S, Kuh, D, Kusters, CDJ, Levine, ME, Lu, AT, Manson, JE, Quach, A, Ritz, BR, Salfati, E, Singleton, AB, Teschendorff, AE, Widschwendter, M, Wong, A   +18 more
core   +1 more source

Accelerated epigenetic aging in Werner syndrome. [PDF]

, 2017
Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia, Haaf, Thomas, Horvath, Steve, Maierhofer, Anna, Martin, George M, Oshima, Junko   +5 more
core   +1 more source

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Epigenetics, 2019
Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in ...
Gabriel Sturm, Andres Cardenas, Marie-Abèle Bind, Steve Horvath, Shuang Wang, Yunzhang Wang, Sara Hägg, Michio Hirano, Martin Picard   +8 more
doaj   +1 more source