Results 51 to 60 of about 5,479,707 (298)
Frontiers in Genetics, 2023 Aberrant DNA methylation (DNAm) is known to be associated with the aetiology of cancer, including colorectal cancer (CRC). In the past, the availability of open access data has been the main driver of innovative method development and research training ...
Tyas Arum Widayati +8 more
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Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences [PDF]
, 2012 Genetic-epidemiological studies on monozygotic (MZ) twins have been used for decades to tease out the relative contributions of genes and the environment to a trait.
Morahan, JM +13 more
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Frontiers in Aging Neuroscience, 2023 IntroductionThe proportion of older adults within society is sharply increasing and a better understanding of how we age starts to be critical. However, given the paucity of longitudinal studies with both neuroimaging and epigenetic data, it remains ...
Klara Mareckova +11 more
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Role of histone methylation in paternal transmission of epigenetic information [PDF]
, 2010 During the development of multi-cellular organisms, one genome gives rise to multiple differentiated cell types. This is achieved by sequence specific transcription factors and different epigenetic mechanisms, which collaborate in reading the genetic ...
Brykczynska, Urszula
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Epigenetic mutation load is weakly correlated with epigenetic age acceleration [PDF]
, 2020 DNA methylation (DNAm) age estimators are widely used to study aging-related conditions. It is not yet known whether DNAm age is associated with the accumulation of stochastic epigenetic mutations (SEMs), which reflect dysfunctions of the epigenetic ...
Yan, Qi +6 more
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Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Epigenetics, 2019 Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in ...
Gabriel Sturm +8 more
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Epigenetics and Immunometabolism in Diabetes and Aging [PDF]
Antioxidants & Redox Signaling, 2018 A strong relationship between hyperglycemia, impaired insulin pathway, and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation. Immunometabolic pathways link these pathogenic processes and pose important potential therapeutic targets.
Guzik, Tomasz J, Cosentino Francesco
openaire +6 more sources
Immuno-Epigenetic Markers for Infectious Diseases
, 2020 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.
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Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression [PDF]
, 2014 Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-responsiveness to growth inhibitory signals. Both genetic and epigenetic changes
de Las Heras, Jose Ignacio +6 more
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Epigenetics, 2021 Background: We investigated the association between prenatal GDM exposure and offspring DNA methylation (DNAm) age at 3–10 years of age in the Tianjin GDM Observational Study.
Stephanie Shiau +13 more
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