Results 41 to 50 of about 365,239 (262)

Exercise epigenetics and the foetal origins of disease [PDF]

, 2014
Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
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DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis [PDF]

, 2014
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been ...
Bronsky, Jiri, Ferry, George D., Frank, Eibe, Harris, R. Alan, Kaplan, Jess L., Kellermayer, Richard, Mir, Sabina A.V., Nagy-Szakal, Dorottya, Opekun, Antone, Szigeti, Reka, Winter, Harland   +10 more
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Longitudinal study of epigenetic aging and its relationship with brain aging and cognitive skills in young adulthood

Frontiers in Aging Neuroscience, 2023
IntroductionThe proportion of older adults within society is sharply increasing and a better understanding of how we age starts to be critical. However, given the paucity of longitudinal studies with both neuroimaging and epigenetic data, it remains ...
Klara Mareckova, Klara Mareckova, Anna Pacinkova, Anna Pacinkova, Radek Marecek, Ludmila Sebejova, Lydie Izakovicova Holla, Jana Klanova, Milan Brazdil, Milan Brazdil, Yuliya S. Nikolova, Yuliya S. Nikolova   +11 more
doaj   +1 more source

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study [PDF]

, 2016
Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood.
Bacalini, MARIA GIULIA, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Capri, Miriam, Ciccarone, Fabio, Dollé, Martijn, Franceschi, Claudio, Gonos, Efstathios S, Grubeck Loebenstein, Beatrix, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Hurme, Mikko, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno Villanueva, María, Reale, Anna, Schӧn, Christiane, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Zampieri, Michele   +26 more
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DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. [PDF]

, 2020
Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains ...
Coppola, Giovanni, Horvath, Steve, Jones, D Leanne, Lewis, Sophia K, Martin, Martin G, Nachun, Daniel   +5 more
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Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARKAGE Study [PDF]

, 2016
Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in ...
Bacalini, Maria Giulia, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Ciccarone, Fabio, Dollé, Martijn E.T., Franceschi, Claudio, Gonos, Efstathios S, Grune, Tilman, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno-Villanueva, María, Reale, Anna, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Valentini, Elisabetta, Zampieri, Michele   +24 more
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Prenatal and early life influences on epigenetic age in children:a study of mother-offspring pairs from two cohort studies [PDF]

, 2015
DNA methylation-based biomarkers of aging are highly correlated with actual age. Departures of methylation-estimated age from actual age can be used to define epigenetic measures of child development or age acceleration (AA) in adults.
Gaunt, Tom R, Hemani, Gibran, Horvath, Steve, Kunze, Sonja, Lyttleton, Oliver, McArdle, Wendy L, Nohr, Ellen A, Peters, Annette, Relton, Caroline L, Ring, Susan M, Sharp, Gemma C, Simpkin, Andrew J, Smith, George Davey, Sorensen, Thorkild, Suderman, Matthew, Tilling, Kate, Waldenberger, Melanie, Ward-Caviness, Cavin   +17 more
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Prenatal gestational diabetes mellitus exposure and accelerated offspring DNA methylation age in early childhood

Epigenetics, 2021
Background: We investigated the association between prenatal GDM exposure and offspring DNA methylation (DNAm) age at 3–10 years of age in the Tianjin GDM Observational Study.
Stephanie Shiau, Leishen Wang, Huikun Liu, Yinan Zheng, Alex Drong, Brian T. Joyce, Jun Wang, Weiqin Li, Junhong Leng, Yun Shen, Ru Gao, Gang Hu, Lifang Hou, Andrea A. Baccarelli   +13 more
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Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes

Frontiers in Genetics, 2023
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE.
Wan-Yu Lin, Wan-Yu Lin, Wan-Yu Lin
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Women's perception, attitudes, and intended behavior towards predictive epigenetic risk testing for female cancers in 5 European countries: A cross-sectional online survey [PDF]

, 2019
BACKGROUND: Epigenetic markers might be used for risk-stratifying cancer screening and prevention programs in the future. Although the clinical utility of consequent epigenetic tests for risk stratification is yet to be proven, successful adoption into ...
Pashayan, N., Rebitschek, F., Wegwarth, O., Widschwendter, M.   +3 more
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