Results 21 to 30 of about 5,479,707 (298)

Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome

Molecular Genetics & Genomic Medicine, 2022
Background Nicolaides–Baraitser syndrome (NCBRS) is a rare disorder characterized by neurodevelopmental delays, seizures, and diverse physical characteristics. The DNA methylation (DNAm) profile in NCBRS is significantly different.
Yutaka Shinko, Satoshi Okazaki, Ikuo Otsuka, Tadasu Horai, Saehyeon Kim, Takaki Tanifuji, Akitoyo Hishimoto   +6 more
doaj   +1 more source

The epigenetics of aging and neurodegeneration [PDF]

Progress in Neurobiology, 2015
Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, as well as in more dynamic processes related to cognition ...
Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch HW, Mastroeni D, Coleman P, Lemere CA, Hof PR, van den Hove DL, Rutten BP   +10 more
openaire   +4 more sources

Accelerated epigenetic aging and myopenia in young adult cancer survivors

Cancer Medicine, 2023
Background Young adult cancer survivors experience early aging‐related morbidities and mortality. Biological aging biomarkers may identify at‐risk survivors and increase our understanding of mechanisms underlying this accelerated aging.
Stephanie C. Gehle, Daniel Kleissler, Hillary Heiling, Allison Deal, Zongli Xu, Vanessa L. Ayer Miller, Jack A. Taylor, Andrew B. Smitherman   +7 more
doaj   +1 more source

Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation

Toxics, 2021
Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression.
Karin Engström, Yumjirmaa Mandakh, Lana Garmire, Zahra Masoumi, Christina Isaxon, Ebba Malmqvist, Lena Erlandsson, Stefan R. Hansson   +7 more
doaj   +1 more source

Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes

Frontiers in Psychiatry, 2022
Long-term studies have shown significantly lower mortality rates in patients with continuous clozapine (CLZ) treatment than other antipsychotics. We aimed to evaluate epigenetic age and DNA methylome differences between CLZ-treated patients and those ...
Blanca Estela Pérez-Aldana, José Jaime Martínez-Magaña, Yerye Gibrán Mayén-Lobo, David José Dávila-Ortiz de Montellano, Carlos Luis Aviña-Cervantes, Alberto Ortega-Vázquez, Alma Delia Genis-Mendoza, Emmanuel Sarmiento, Ernesto Soto-Reyes, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zarate, Thelma Beatriz González-Castro, Humberto Nicolini, Humberto Nicolini, Marisol López-López, Nancy Monroy-Jaramillo   +15 more
doaj   +1 more source

Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Francesco Spallotta, Spallotta, Francesco, Gaetano, Carlo, Sergio Valente, Chiara Cencioni, Antonello Mai, Cencioni, Chiara, Valente, Sergio, Carlo Gaetano, Mai, Antonello, Martelli, Fabio, Zeiher, Andreas M., Fabio Martelli, Andreas Zeiher   +13 more
core   +1 more source

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]

, 2015
BACKGROUND: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Deary, Ian J., Pattie, Alison, Horvath, Steve, Wray, Naomi R., Harris, Sarah E., Starr, John M., Marioni, Riccardo E, McRae, Allan F, Starr, John M, Murphy, Lee, Ritchie, Stuart J., Muniz-Terrera, Graciela, McRae, Allan F., Ritchie, Stuart J, Marioni, Riccardo E., Taylor, Adele, Deary, Ian J, Visscher, Peter M, Corley, Janie, Murphy, Lee; id_orcid, Redmond, Paul, Wray, Naomi R, Visscher, Peter M., Gibson, Jude, Cox, Simon R, Shah, Sonia, Cox, Simon R., Harris, Sarah E   +27 more
core   +1 more source

Epigenetic regulation of adaptive responses of forest tree species to the environment [PDF]

, 2013
Epigenetic variation is likely to contribute to the phenotypic plasticity and adaptative capacity of plant species, and may be especially important for long-lived organisms with complex life cycles, including forest trees.
Maury, Stéphane, Bräutigam, Katharina, Antje Rohde, M. Ángeles Guevara, Dolores Abarca, Rohde, Antje, Fluch, S., Fluch, Silvia, Fraga, Mario F., Clément Lafon‐Placette, Johnsen, Oystein, Lafon-Placette, Clément, Jose, Gutiérrez-Marcos, Angeles Guevara, M., Campbell, Malcolm M., Fossdal, Carl G., Steven H. Strauss, Bräutigam, K., Fossdal, C. G., Abarca, Dolores, Mirouze, M., Katharina Bräutigam, Malcolm M. Campbell, Lafon-Placette, C., Vining, Kelly J., Gutierrez Marcos, Jose, Campbell, M. M., Rohde, A., Fernandez Fraga, Mario, José Gutiérrez Marcos, Marcos, J. G., Marie Mirouze, Silvia Fluch, Fraga, Mario Fernández, Cervera, María-Teresa, Díaz-Sala, Carmen, María‐Teresa Cervera, Guevara, M. Ángeles, Cervera, María Teresa, Johnsen, Øystein, Strauss, Steven H., Mario Fernández Fraga, Braeutigam, Katharina, Guevara, M Ángeles, Øystein Johnsen, Stéphane Maury, Mirouze, Marie, Kelly J. Vining, Johnsen, O., Vining, K. J., Carl G. Fossdal, Carmen Díaz‐Sala   +51 more
core   +1 more source

Epigenetics, aging, and autoimmunity [PDF]

Autoimmunity, 2008
Immune senescence is associated with a decline in T- and B-cell immune responses. It is, therefore, perhaps surprising that aging is linked to the appearance of serological and clinical autoimmunity. Here we review the mechanisms that contribute to the increase in inflammatory and autoimmune responses in aging.
Raymond L, Yung, Annabelle, Julius
openaire   +2 more sources

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Ducasse, Miryam, Brown, Mark A., Ducasse Miryam, Brown Mark A   +3 more
core   +1 more source