Results 21 to 30 of about 365,239 (262)

The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease

Frontiers in Aging Neuroscience, 2022
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease with variable clinical manifestations. Recent studies highlighted the contribution of epigenetic alterations to HD progress and onset. The potential crosstalk between different
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Taheri, Kaveh Ebrahimzadeh, Rezvan Noroozi   +7 more
doaj   +1 more source

Influence of obesity on biological age in patients with arterial hypertension

Arterial Hypertension, 2023
BACKGROUND: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension.
Olena Kolesnikova, Olga Zaprovalna, Tetiana Bondar, Anna Potapenko   +3 more
doaj   +1 more source

Assessing brain and biological aging trajectories associated with Alzheimer’s disease

Frontiers in Neuroscience, 2022
The development of effective treatments to prevent and slow Alzheimer’s disease (AD) pathogenesis is needed in order to tackle the steady increase in the global prevalence of AD.
Winnie S. Liang, Winnie S. Liang, Laura H. Goetz, Laura H. Goetz, Nicholas J. Schork, Nicholas J. Schork   +5 more
doaj   +1 more source

Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation

Toxics, 2021
Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression.
Karin Engström, Yumjirmaa Mandakh, Lana Garmire, Zahra Masoumi, Christina Isaxon, Ebba Malmqvist, Lena Erlandsson, Stefan R. Hansson   +7 more
doaj   +1 more source

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort

Epigenetics, 2022
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood.
Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A. Collender, Jamaji C. Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas   +9 more
doaj   +1 more source

Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes

Frontiers in Psychiatry, 2022
Long-term studies have shown significantly lower mortality rates in patients with continuous clozapine (CLZ) treatment than other antipsychotics. We aimed to evaluate epigenetic age and DNA methylome differences between CLZ-treated patients and those ...
Blanca Estela Pérez-Aldana, José Jaime Martínez-Magaña, Yerye Gibrán Mayén-Lobo, David José Dávila-Ortiz de Montellano, Carlos Luis Aviña-Cervantes, Alberto Ortega-Vázquez, Alma Delia Genis-Mendoza, Emmanuel Sarmiento, Ernesto Soto-Reyes, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zarate, Thelma Beatriz González-Castro, Humberto Nicolini, Humberto Nicolini, Marisol López-López, Nancy Monroy-Jaramillo   +15 more
doaj   +1 more source

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]

, 2015
Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Corley, Janie, Cox, Simon R, Deary, Ian J, Gibson, Jude, Harris, Sarah E, Horvath, Steve, Marioni, Riccardo E, McRae, Allan F, Muniz-Terrera, Graciela, Murphy, Lee, Pattie, Alison, Redmond, Paul, Ritchie, Stuart J, Shah, Sonia, Starr, John M, Taylor, Adele, Visscher, Peter M, Wray, Naomi R   +17 more
core   +1 more source

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort [PDF]

, 2019
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation ...
Banszerus, Verena L., Demuth, Ilja, König, Maximilian, Salewsky, Bastian, Vetter, Valentin M.   +4 more
core   +1 more source

Evaluation of Epigenetic Age Based on DNA Methylation Analysis of Several CpG Sites in Ukrainian Population

Frontiers in Genetics, 2022
Epigenetic clocks are the models, which use CpG methylation levels for the age prediction of an organism. Although there were several epigenetic clocks developed there is a demand for development and evaluation of the relatively accurate and sensitive ...
N. Kuzub, V. Smialkovska, V. Momot, V. Moseiko, O. Lushchak, A. Koliada, A. Koliada   +6 more
doaj   +1 more source

Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. [PDF]

, 2020
Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease.
Park, Hannah Lui
core   +1 more source