Results 11 to 20 of about 5,479,707 (298)
PLoS ONE, 2011 From the moment of conception, we begin to age. A decay of cellular structures, gene regulation, and DNA sequence ages cells and organisms. DNA methylation patterns change with increasing age and contribute to age related disease.
Sven Bocklandt +6 more
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International Journal of General Medicine, 2023 Germán Alberto Nolasco-Rosales,1,* Cecilia Yazmin Alonso-García,1,* David Gustavo Hernández-Martínez,1 Mario Villar-Soto,2 José J Martínez-Magaña,3 Alma Delia Genis-Mendoza,4 Thelma Beatriz González-Castro,5 Carlos Alfonso Tovilla-Zarate,6 ...
Nolasco-Rosales GA +11 more
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Current Genomics, 2015 The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic patterns during aging) is the gradual decrease of global DNA methylation. Aging cells, different tissue types, as well as a variety of human diseases possess their own distinct DNA methylation profiles, although the functional impact of these is not always clear.
Sierra, Marta I. +2 more
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Epigenetic age prediction [PDF]
Aging Cell, 2021 AbstractAdvanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more is known about the molecular basis of any of these groups of diseases than the changes that accompany ageing itself. Progress in molecular ageing research was slow because the tools predicting whether someone aged slowly or fast ...
Daniel J. Simpson, Tamir Chandra
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Epigenetic age prediction and rejuvenation [PDF]
, 2021 Ageing is a complex, multi-faceted process that afflicts all humans. It invariably increases susceptibility to a range of diseases such as cancer and neurological disorders.
Simpson, Daniel J.
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Science Advances, 2016 Researchers review how random changes and our environment (for example, diet) determines our life span.
Pal, Sangita, Tyler, Jessica K.
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Oocyte ageing and epigenetics [PDF]
Reproduction, 2015 Abstract It has become a current social trend for women to delay childbearing. However, the quality of oocytes from older females is compromised and the pregnancy rate of older women is lower. With the increased rate of delayed childbearing, it is becoming more and more crucial to understand the mechanisms underlying the compromised ...
Ge, Zhao-Jia +3 more
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Frontiers in Medicine, 2022 Observational data from China, the United States, France, and Italy suggest that chronological age is an adverse COVID-19 outcome risk factor, with older patients having a higher severity and mortality rate than younger patients. Most studies have gotten
Wenchang Xu +6 more
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Experimental Gerontology, 2010 Epigenetics is the field of study of phenotypic changes that may occur in a cell independent of changes in the underlying genetic code. In the strictest sense, these phenotypic changes are inherited and stable through rounds of DNA replication and cell division.
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Assessing brain and biological aging trajectories associated with Alzheimer’s disease
Frontiers in Neuroscience, 2022 The development of effective treatments to prevent and slow Alzheimer’s disease (AD) pathogenesis is needed in order to tackle the steady increase in the global prevalence of AD.
Winnie S. Liang +5 more
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