Results 61 to 70 of about 365,239 (262)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease

Frontiers in Aging
IntroductionDNA methylation (DNAm) age clocks are powerful tools for measuring biological age, providing insights into aging risks and outcomes beyond chronological age.
David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson   +5 more
doaj   +1 more source

Epigenetic predictor of age.

PLoS ONE, 2011
From the moment of conception, we begin to age. A decay of cellular structures, gene regulation, and DNA sequence ages cells and organisms. DNA methylation patterns change with increasing age and contribute to age related disease.
Sven Bocklandt, Wen Lin, Mary E Sehl, Francisco J Sánchez, Janet S Sinsheimer, Steve Horvath, Eric Vilain   +6 more
doaj   +1 more source

Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. [PDF]

, 2017
BackgroundThe study of epigenetic processes and mechanisms present a dynamic approach to assess complex individual variation in obesity susceptibility. However, few studies have examined epigenetic patterns in preschool-age children at-risk for obesity ...
Barkin, Shari L, Guo, Yan, Non, Amy L, Oelsner, Kathryn Tully, To, Sophie Bao-Chieu   +4 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Environmental chemical exposures and breast cancer [PDF]

, 2016
As a hormone-sensitive condition with no single identifiable cause, breast cancer is a major health problem. It is characterized by a wide range of contributing factors and exposures occurring in different combinations and strengths across a lifetime ...
Plant, J, Stanley, E, Voulvoulis, N
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Stress related epigenetic changes may explain opportunistic success in biological invasions in Antipode mussels [PDF]

, 2018
Different environmental factors could induce epigenetic changes, which are likely involved in the biological invasion process. Some of these factors are driven by humans as, for example, the pollution and deliberate or accidental introductions and others
A Ardura, A Ardura, A Brenkert, A Pecinka, A Pérez-Figueroa, A Salmon, A Zaiko, A Zemach, AB Nicotra, AG Marsh, AK Sakai, AL Liebl, AR Linde, B Bec, B Liu, BM Turner, BR Wilson, CE Braby, CE Lee, CL Richards, DH Lim, DJ Madariaga, DL Strayer, DM Updegraff, E Briski, E Malone, F Devloo-Delva, F Valladares, FJ Santaclara, FT Chan, G Riviere, I Pejovic, J Atalah, J Fulneček, JA Rusiecki, JC Rice, JH McDonald, JM Jones, K Gérard, KJF Verhoeven, KV Kardong, L Alessa, L Excoffier, L Manti, L Miralles, M Barbieri, MA Khadim, MB Vandegehuchte, MJ Lexer, MR Gavery, MR Gavery, O Bossdorf, O Broennimann, P Colosimo, P García-Fernández, P Moran, PA Gardner, PA Jones, R Alquezar, R Karan, R Peakall, R Peakall, R Tingley, RA Zerebecki, S Gofas, S Gollasch, S Pascual, SCH Barrett, SJ Bownes, T Kohama, TJ Hilbish, V Chinnusamy, V Suarez-Ulloa, Y Sun, Ø Hammer   +74 more
core   +2 more sources

Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]

, 2020
During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana, Au, Dawn, Benmarhnia, Tarik, Cardiff, Robert D, Chavez, Tanya, Dietze, Eric C, Doan, Stacey, Jankowska, Marta M, Jones, Veronica, McCune, Jeannine S, Natarajan, Rama, Nunez, Alan, Resto, Cristal, Sanchez, Angelica, Seewaldt, Victoria L, Serrano, Mayra, Sistrunk, Christopher, Thai, Christine, Tomsic, Jerneja, Yang, Jiue-An   +19 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source