Results 61 to 70 of about 5,479,707 (298)

Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes

Frontiers in Genetics, 2023
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE.
Wan-Yu Lin, Wan-Yu Lin, Wan-Yu Lin
doaj   +1 more source

Epigenetic regulation during fetal femur development: DNA methylation matters [PDF]

, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
Oreffo Richard O. C., Oreffo, Richard O. C., Antonio Gonzalez, González Martínez-Pedrayo, Antonio, Imagawa, K., Richard O C Oreffo, de Andrés María C., Gonzalez, A., Roach Helmtrud I., Wilson, David I., Kingham, Emmajayne, Oreffo, R.O., Kingham Emmajayne, Helmtrud I Roach, Oreffo, Richard O C, Gomez-Reino, J.J., Emmajayne Kingham, Kei Imagawa, María C de Andrés, Wilson, D.I., Roach, Helmtrud I, Wilson David I., de Andrés, María C., Imagawa, Kei, Roach, Helmtrud I., De Andrés González, Mª Carmen, Imagawa Kei, Wilson, David I, Neves, Nuno M., David I Wilson, Gonzalez, Antonio, Roach, H.I., Kingham, E., Gonzalez Antonio, de Andrés, M.C.   +34 more
core   +1 more source

DNA methylation patterns in cord blood DNA and body size in childhood. [PDF]

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND ...
Pearce, M., Mark S. Pearce (177539), Ness, Andy R, Caroline L Relton, St Pourcain, B., Joseph Trakalo (177545), Shaheen Seif O., Embleton, N., Swan, DC, Ness, AR, George Davey Smith (82619), Seif O. Shaheen (177559), Shaheen, S., Relton, Caroline L, Ring, SM, Relton, C., Jon H Tobias, Swan, D., Sayers, AE, Alexandra Groom, Caroline L. Relton (174120), Susan M. Ring (116089), Embleton Nicholas D., Alexandra Groom (174101), Andy R Ness, Andy R. Ness (177551), Ring Susan M., Beate St. Pourcain (152905), Sayers, Adrian E, Tobias Jon H., Ness Andy R., Trakalo, J, St Pourcain, B, Sayers Adrian E., Groom, A., Tobias, Jonathan H, Relton Caroline L., St. Pourcain Beate, St Pourcain, M U B, Nicholas D Embleton, Tobias, J., Jon H. Tobias (153172), Northstone, K., Beate St Pourcain, Northstone, K, Davey Smith George, Trakalo Joseph, Groom Alexandra, Joseph Trakalo, Sayers, A., Kate Northstone (74777), Tobias, JH, Davey Smith, George, Groom, A, Ring, Susan M, Davey Smith, G, Pearce, MS, Northstone, Kate, Nicholas D. Embleton (177535), Susan M Ring, Pearce Mark S., Daniel C Swan, Ness, A., Swan Daniel C., Mark S Pearce, Northstone Kate, Relton, CL, Adrian E Sayers, Shaheen, SO, George Davey Smith, Trakalo, J., Adrian E. Sayers (177532), Embleton, ND, Davey Smith, G., Kate Northstone, Seif O Shaheen, Ring, S., Daniel C. Swan (124594)   +77 more
core   +1 more source

BayesAge: A maximum likelihood algorithm to predict epigenetic age

Frontiers in Bioinformatics
Introduction: DNA methylation, specifically the formation of 5-methylcytosine at the C5 position of cytosine, undergoes reproducible changes as organisms age, establishing it as a significant biomarker in aging studies. Epigenetic clocks, which integrate
Lajoyce Mboning, Liudmilla Rubbi, Michael Thompson, Louis-S. Bouchard, Matteo Pellegrini   +4 more
doaj   +1 more source

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease

Frontiers in Aging
IntroductionDNA methylation (DNAm) age clocks are powerful tools for measuring biological age, providing insights into aging risks and outcomes beyond chronological age.
David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Sperm epigenetics and aging

Translational Andrology and Urology, 2018
Advanced paternal age has very real consequences in fertility, embryogenesis, and even offspring health. Specifically, advanced paternal age has been linked to delayed time to pregnancy and in some studies even appears to be linked to a decreased likelihood of achieving a pregnancy.
Jenkins, Timothy G., Aston, Kenneth I., Carrell, Douglas T.   +2 more
openaire   +2 more sources

The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues [PDF]

, 2007
Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation within intron 1 of the FXN gene, leading to reduced expression of frataxin protein.
Pook, MA, Mouro Pinto, R, Al-Mahdawi, S, Trabzuni, D, Sandi, C, S. Al-Mahdawi, D. Trabzuni, S. Lymperi, D. Varshney, O. Ismail, C. Sandi, R. M. Pinto, M. Pook   +12 more
core   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source